CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9160
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha inhibitor AGN-PC-00JEPZ family
No. of Seeds 42 No. of Other Members 3
Family Centroid CFAMM00393347 Functional Category Bioactive
Superfamily Prothrombin and cGMP-specific 3',5'-cyclic phosphodiesterase Binder Superfamily
Class Class 2472

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
SB1518 family 7 103
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
DNA ligase Inhibitor 7-(4-methoxyphenyl)pteridine-2,4-diol Family 1 4
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Prothrombin inhibitor AGN-PC-073H0Z family 9 6
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 4
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylet... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-(2-hy... 24 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Transient receptor potential cation channel subfamily V member... 2 4
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Calcitonin gene-related peptide type 1 receptor ligand N-[5-(4... 3 1
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-metho... 1 0


External ID

Functional Category

Molecule Name

CFAMM00393321 CHEMBL602120 Bioactive SureCN1969924
CFAMM00393334 CHEMBL567469 Bioactive AGN-PC-07CQO3
CFAMM00393347 CHEMBL567252 Bioactive AGN-PC-00JEPZ
CFAMM00393327 CHEMBL590545 Bioactive AGN-PC-04URS5
CFAMM00393340 CHEMBL585918 Bioactive AGN-PC-00JF7Q
CFAMM00393354 CHEMBL569492 Bioactive SureCN5814375
CFAMM00393333 CHEMBL551052 Bioactive AGN-PC-00JEY3
CFAMM00393320 CHEMBL566797 Bioactive AGN-PC-00JEJC
CFAMM00393346 CHEMBL584270 Bioactive AGN-PC-00JEY5
CFAMM00393326 CHEMBL567447 Bioactive AGN-PC-00JEJB
CFAMM00393339 CHEMBL585327 Bioactive AGN-PC-00JEJA
CFAMM00393353 CHEMBL567471 Bioactive SureCN8247637
CFAMM00393319 CHEMBL590787 Bioactive AGN-PC-04UTMN
CFAMM00393332 CHEMBL566375 Bioactive SureCN5814767
CFAMM00393359 CHEMBL589069 Bioactive SureCN1970594
CFAMM00393345 CHEMBL1916296 Bioactive 4-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[4,3-d]pyrimidin-2-one
CFAMM00393325 CHEMBL567445 Bioactive AGN-PC-00JF5B
CFAMM00393351 CHEMBL565306 Bioactive SureCN8250678
CFAMM00393318 CHEMBL571469 Bioactive AGN-PC-00JEH7
CFAMM00393331 CHEMBL569481 Bioactive AGN-PC-00JEY4
CFAMM00393344 CHEMBL1916291 Bioactive 7-(6-methoxypyridin-3-yl)-4-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[4,3-d]pyrimidin-2-one
CFAMM00393358 CHEMBL590544 Bioactive AGN-PC-04URS4
CFAMM00393337 CHEMBL591942 Bioactive SureCN1970899
CFAMM00393350 CHEMBL565305 Bioactive AGN-PC-07CQNQ
CFAMM00393317 CHEMBL583854 Bioactive SureCN5813676
CFAMM00393330 CHEMBL590037 Bioactive AGN-PC-04UTDC
CFAMM00393343 CHEMBL1916290 Bioactive 7-(6-methoxypyridin-3-yl)-4-(2-propan-2-yloxyethylamino)-1-(2-propoxyethyl)pyrido[4,3-d]pyrimidin-2-one
CFAMM00393357 CHEMBL565308 Bioactive AGN-PC-00JEJE
CFAMM00393323 CHEMBL589797 Bioactive SureCN1970610
CFAMM00393336 CHEMBL569264 Bioactive AGN-PC-00JF7R
CFAMM00393349 CHEMBL590280 Bioactive AGN-PC-04UTML
CFAMM00393329 CHEMBL590036 Bioactive SureCN1971462
CFAMM00393342 CHEMBL1916293 Bioactive 4-[(4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[4,3-d]pyrimidin-2-one
CFAMM00393356 CHEMBL566367 Bioactive SureCN8250248
CFAMM00393322 CHEMBL591501 Bioactive GE-0036
CFAMM00393335 CHEMBL591477 Bioactive SureCN1971307
CFAMM00393328 CHEMBL566598 Bioactive AGN-PC-00JF5D
CFAMM00393341 CHEMBL1916292 Bioactive AGN-PC-00JELN
CFAMM00393355 CHEMBL571913 Bioactive AGN-PC-00JF7P

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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