CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9161
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha inhibitor AGN-PC-07CQNZ family
No. of Seeds 24 No. of Other Members 5
Family Centroid CFAMM00302575 Functional Category Bioactive
Superfamily Prothrombin and cGMP-specific 3',5'-cyclic phosphodiesterase Binder Superfamily
Class Class 2472

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
SB1518 family 7 103
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
DNA ligase Inhibitor 7-(4-methoxyphenyl)pteridine-2,4-diol Family 1 4
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylet... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-(2-hy... 24 0
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Growth hormone secretagogue receptor type 1 and Potassium volt... 3 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Melanin-concentrating hormone receptor 1 ligand 1-[6-[(3R)-3-a... 1 5
Corticotropin-releasing factor receptor 1 ligand 8-(2-chloro-4... 13 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Transient receptor potential cation channel subfamily V member... 2 3
Corticotropin-releasing factor receptor 1 ligand N-[(1R,2S)-2-... 3 0
Calcitonin gene-related peptide type 1 receptor ligand N-[5-(4... 3 1
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393367 CHEMBL1916295 Bioactive 4-[(4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,2-d]pyrimidin-2-one
CFAMM00393366 CHEMBL1916297 Bioactive 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one
CFAMM00393365 CHEMBL560516 Bioactive AGN-PC-073FM0
CFAMM00393369 CHEMBL1916298 Bioactive 4-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,2-d]pyrimidin-2-one
CFAMM00393368 CHEMBL567251 Bioactive AGN-PC-07CQPC

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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