CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9162
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-(2-hydroxyethylamino)-3-(6-methoxypyridin-3-yl)-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-6-one family
No. of Seeds 24 No. of Other Members 0
Family Centroid CFAMM00393371 Functional Category Bioactive
Superfamily Prothrombin and cGMP-specific 3',5'-cyclic phosphodiesterase Binder Superfamily
Class Class 2472

Cousin Family NamesSeedsMembers
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylet... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Calcitonin gene-related peptide type 1 receptor ligand N-[5-(4... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393373 CHEMBL1916303 Bioactive 3-[[3-(6-methoxypyridin-3-yl)-6-oxo-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-8-yl]amino]propanoic acid
CFAMM00393386 CHEMBL1916478 Bioactive 2-[[3-(6-methoxypyridin-3-yl)-6-oxo-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-8-yl]amino]-N,N-dimethylacetamide
CFAMM00393379 CHEMBL1916489 Bioactive 1-[3-(6-methoxypyridin-3-yl)-6-oxo-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-8-yl]piperidine-3-carboxylic acid
CFAMM00393392 CHEMBL1916473 Bioactive 8-[4-(2-hydroxyethyl)piperazin-1-yl]-3-(6-methoxypyridin-3-yl)-5-[2-(2,2,2-trifluoroethoxy)ethyl]pyrimido[5,4-c]pyridazin-6-one
CFAMM00393372 CHEMBL1916302 Bioactive 8-(4-hydroxypiperidin-1-yl)-3-(6-methoxypyridin-3-yl)-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-6-one
CFAMM00393385 CHEMBL1916490 Bioactive 2-[4-[3-(6-methoxypyridin-3-yl)-6-oxo-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-8-yl]piperazin-1-yl]acetic acid
CFAMM00393378 CHEMBL1916485 Bioactive (1S,2R)-2-[[3-(6-methoxypyridin-3-yl)-6-oxo-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-8-yl]amino]cyclohexane-1-carboxylic acid
CFAMM00393391 CHEMBL1916299 Bioactive 3-(6-methoxypyridin-3-yl)-8-(2-morpholin-4-ylethylamino)-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-6-one
CFAMM00393371 CHEMBL1916301 Bioactive 8-(2-hydroxyethylamino)-3-(6-methoxypyridin-3-yl)-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-6-one
CFAMM00393384 CHEMBL1916480 Bioactive 2-[[5-(2-ethoxyethyl)-3-(6-methoxypyridin-3-yl)-6-oxopyrimido[5,4-c]pyridazin-8-yl]amino]-N,N-dimethylacetamide
CFAMM00393377 CHEMBL1916486 Bioactive 4-[[3-(6-methoxypyridin-3-yl)-6-oxo-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-8-yl]amino]cyclohexane-1-carboxylic acid
CFAMM00393390 CHEMBL1916474 Bioactive 5-(2-ethoxyethyl)-8-[4-(2-hydroxyethyl)piperazin-1-yl]-3-(6-methoxypyridin-3-yl)pyrimido[5,4-c]pyridazin-6-one
CFAMM00393370 CHEMBL1916300 Bioactive 3-(6-methoxypyridin-3-yl)-8-(piperidin-4-ylamino)-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-6-one
CFAMM00393383 CHEMBL1916487 Bioactive 2-[1-[3-(6-methoxypyridin-3-yl)-6-oxo-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-8-yl]piperidin-4-yl]acetic acid
CFAMM00393376 CHEMBL1916481 Bioactive (2R)-2-[[3-(6-methoxypyridin-3-yl)-6-oxo-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-8-yl]amino]propanoic acid
CFAMM00393389 CHEMBL1916477 Bioactive 5-(2-ethoxyethyl)-8-[(4-hydroxycyclohexyl)amino]-3-(6-methoxypyridin-3-yl)pyrimido[5,4-c]pyridazin-6-one
CFAMM00393382 CHEMBL1916483 Bioactive 3-[[3-(6-methoxypyridin-3-yl)-6-oxo-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-8-yl]amino]cyclohexane-1-carboxylic acid
CFAMM00393375 CHEMBL1916482 Bioactive 2-[[3-(6-methoxypyridin-3-yl)-6-oxo-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-8-yl]amino]-2-methylpropanoic acid
CFAMM00393388 CHEMBL1916476 Bioactive 8-[(4-hydroxycyclohexyl)amino]-3-(6-methoxypyridin-3-yl)-5-[2-(2,2,2-trifluoroethoxy)ethyl]pyrimido[5,4-c]pyridazin-6-one
CFAMM00393381 CHEMBL1916484 Bioactive (1R,2R)-2-[[3-(6-methoxypyridin-3-yl)-6-oxo-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-8-yl]amino]cyclohexane-1-carboxylic acid
CFAMM00393374 CHEMBL1916304 Bioactive 8-[4-(2-hydroxyethyl)piperazin-1-yl]-3-(6-methoxypyridin-3-yl)-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-6-one
CFAMM00393387 CHEMBL1916479 Bioactive 2-[[3-(6-methoxypyridin-3-yl)-6-oxo-5-[2-(2,2,2-trifluoroethoxy)ethyl]pyrimido[5,4-c]pyridazin-8-yl]amino]-N,N-dimethylacetamide
CFAMM00393380 CHEMBL1916488 Bioactive 1-[3-(6-methoxypyridin-3-yl)-6-oxo-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-8-yl]piperidine-4-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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