CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9184
Family Name Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn inhibitor (E)-4-(dimethylamino)-N-[7-fluoro-4-(2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00393507 Functional Category Bioactive
Superfamily Vascular endothelial growth factor receptor 2 and Tyrosine-protein kinase Lyn Binder Superfamily
Class Class 3054

Cousin Family NamesSeedsMembers
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
AP26113 family 16 90
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
MK-6096 family 3 69
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 and Fibroblast g... 3 11
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 4 3
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Oxytocin receptor ligand AGN-PC-07C71T family 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393507 CHEMBL1916899 Bioactive (E)-4-(dimethylamino)-N-[7-fluoro-4-(2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
CFAMM00393506 CHEMBL1916901 Bioactive (E)-4-(dimethylamino)-N-[7-fluoro-4-(4-fluoro-2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
CFAMM00393505 CHEMBL1916902 Bioactive (E)-4-(dimethylamino)-N-[4-(4-fluoro-2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543