CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9185
Family Name Melanocortin receptor 4 and Melanocortin receptor 5 ligand 3-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]-1,1-dimethylurea family
No. of Seeds 18 No. of Other Members 26
Family Centroid CFAMM00393539 Functional Category Bioactive
Superfamily Melanocortin receptor 4 and Melanocortin receptor 5 Binder Superfamily 4
Class Class 3332

Cousin Family NamesSeedsMembers
Atrial natriuretic peptide receptor 1 Ligand Ataciguat Family 7 45
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
E3 ubiquitin-protein ligase Mdm2 inhibitor (2'R,3R,3'S,5'S)-6-... 17 51
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 4 19
Coagulation factor X inhibitor AGN-PC-04YPWA family 3 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand 2-... 6 9
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Melanocortin receptor 4 and Melanocortin receptor 5 ligand 3-a... 1 9
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Growth hormone secretagogue receptor type 1 ligand N-[4,6-dich... 2 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
Coagulation factor X and Prothrombin inhibitor SureCN6592460 f... 14 1
Coagulation factor X inhibitor SureCN14490781 family 15 0
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Coagulation factor X inhibitor (E)-2-(5-chlorothiophen-2-yl)-N... 6 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 7 5
Urotensin-2 receptor ligand 2-(5-chloro-1-benzothiophen-3-yl)-... 2 4
Melanocortin receptor 4 ligand 2-amino-N-[(2R)-3-(2,4-dichloro... 5 5
DNA-(apurinic or apyrimidinic site) lyase and Cytochrome P450 ... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393544 CHEMBL436122 Bioactive AC1OCFYF
CFAMM00393523 CHEMBL195308 Bioactive 1-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]-3-(2-hydroxyethyl)urea
CFAMM00393522 CHEMBL191701 Bioactive 1-cyclopropyl-3-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]urea
CFAMM00393515 CHEMBL363576 Bioactive 1-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]-3-ethylurea
CFAMM00393528 CHEMBL195734 Bioactive 1-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]-3-[(2-fluorophenyl)methyl]urea
CFAMM00393535 CHEMBL191857 Bioactive 1-tert-butyl-3-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]urea
CFAMM00393548 CHEMBL194393 Bioactive ethyl N-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]carbamate
CFAMM00393514 CHEMBL192464 Bioactive propan-2-yl N-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]carbamate
CFAMM00393527 CHEMBL363190 Bioactive 1-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]-3-propan-2-ylurea
CFAMM00393520 CHEMBL195110 Bioactive N-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]pyrrolidine-1-carboxamide
CFAMM00393519 CHEMBL194990 Bioactive 1-cyclopentyl-3-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]urea
CFAMM00393546 CHEMBL192090 Bioactive methyl 4-[[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]amino]-4-oxobutanoate
CFAMM00393512 CHEMBL363641 Bioactive N-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]benzamide
CFAMM00393525 CHEMBL373099 Bioactive methyl N-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]carbamate
CFAMM00393539 CHEMBL194987 Bioactive 3-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]-1,1-dimethylurea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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