CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM919
Family Name Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)-N-[2-[[(1S)-1-phenylethyl]amino]pyrimidin-4-yl]-2,3-dihydro-1-benzofuran-5-carboxamide family
No. of Seeds 1 No. of Other Members 28
Family Centroid CFAMM00317204 Functional Category Bioactive with Natural Product
Superfamily MK-6096 Superfamily
Class Class 1305

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 5 12
Smoothened homolog Inhibitor LDE225 Family 3 76
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
MK-6096 family 3 69
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Gonadotropin-releasing hormone receptor ligand AGN-PC-034WF4 f... 8 23
Disintegrin and metalloproteinase domain-containing protein 17... 2 6
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Histamine H3 receptor ligand SureCN2784306 family 5 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Metabotropic glutamate receptor 5 ligand AGN-PC-09QLD2 family 1 2
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Prothrombin inhibitor AGN-PC-073H0Z family 9 6
Glucose-dependent insulinotropic receptor and Potassium voltag... 4 0
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
MAP kinase-activated protein kinase 2 inhibitor 4-[4-oxo-8-pip... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Nuclear receptor ROR-gamma and Prelamin-A/C ligand ST50133141 ... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 21
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 5
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Neuropeptide Y receptor type 5 ligand SureCN5430956 family 11 1
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Delta-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 1 0
Neuropeptide Y receptor type 5 ligand SureCN2658856 family 6 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 2 25
Motilin receptor ligand SureCN13392247 family 1 0
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00317204 CHEMBL1093548 Bioactive N-(4-aminobutyl)-N-[2-[[(1S)-1-phenylethyl]amino]pyrimidin-4-yl]-2,3-dihydro-1-benzofuran-5-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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