CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9210
Family Name Cystic fibrosis transmembrane conductance regulator inhibitor (3S)-2-[3-(2-methylpropoxy)benzoyl]-N-(4-pentylphenyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00393730 Functional Category Bioactive
Superfamily Cathepsin K and Cathepsin L1 Binder Superfamily 2
Class Class 2417

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand JT... 14 4
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
Renin Inhibitor Ro-66-1168 Family 10 30
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Integrin beta-1 and Integrin alpha-4 inhibitor (3S)-3-(3,4-dim... 5 61
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Poly [ADP-ribose] polymerase 1 inhibitor 6-[1-(2,3-dihydro-1,4... 1 30
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Kappa-type opioid receptor ligand AGN-PC-09M90I family 2 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Survival motor neuron protein and Alpha-galactosidase A inhibi... 1 4
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QMLE family 5 0
Vasopressin V1b receptor ligand AGN-PC-09QGT9 family 4 123
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-0A9QDC family 2 5
Coagulation factor VII and Prothrombin inhibitor (S)-[(R)-2-(4... 2 8
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
Mitogen-activated protein kinase 14 inhibitor N-[2,4-difluoro-... 4 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1B ligand SureCN5352760 family 2 5
Sodium-dependent serotonin transporter and D(2) dopamine recep... 8 6
Serine/threonine-protein kinase Chk1 inhibitor 2-[9-(4-amino-3... 5 2
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 1 2
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
D(3) dopamine receptor and D(4) dopamine receptor ligand SureC... 3 19
C-C chemokine receptor type 5 ligand dimethyl-[[4-[[7-(4-methy... 7 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 4 4
Leukotriene A-4 hydrolase inhibitor 4-[[(1S,5R)-3-[4-(2-fluoro... 2 2
Mitogen-activated protein kinase 14 inhibitor SureCN4822166 fa... 1 4
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00A4QT fa... 2 0
Mitogen-activated protein kinase 14 inhibitor ITX 5061 free ba... 2 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-04UTCQ fa... 2 1
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Follicle-stimulating hormone receptor ligand (1-acetyl-2,2,4-t... 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00E... 1 2
Mitogen-activated protein kinase 14 inhibitor SureCN1600485 fa... 1 1
Hypoxia-inducible factor 1-alpha inhibitor 2-morpholin-4-yleth... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393730 CHEMBL191926 Bioactive (3S)-2-[3-(2-methylpropoxy)benzoyl]-N-(4-pentylphenyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00393726 CHEMBL366586 Bioactive SureCN3931844

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26223 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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