CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9222
Family Name Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(3-chlorophenoxy)phenyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00393786 Functional Category Bioactive
Superfamily Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Superfamily
Class Class 1049

Cousin Family NamesSeedsMembers
Nuclear factor NF-kappa-B p100 subunit Inhibitor GMX1777 Family 3 7
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
AP26113 family 16 90
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Oxytocin receptor and Vasopressin V1a receptor Ligand PF-32741... 4 36
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Vascular endothelial growth factor receptor 2 and Fibroblast g... 3 11
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Renin inhibitor AGN-PC-09M4GD family 3 4
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-a... 11 13
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Corticotropin-releasing factor receptor 1 ligand N-butyl-9-(2-... 4 5
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 5 1
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VR1 family 1 5
Receptor tyrosine-protein kinase erbB-2 ligand 2-[2-[4-[3-chlo... 4 5
Tyrosine-protein kinase JAK2 inhibitor N-[3-chloro-4-(4-methyl... 2 1
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Wee1-like protein kinase and ALK tyrosine kinase receptor liga... 1 9
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 3
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 2 0
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 14 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 0
Glucagon receptor ligand SureCN2647807 family 3 7
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 4 24
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 0
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJ2 family 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393787 CHEMBL1922901 Bioactive 2-[2-chloro-4-(5H-pyrrolo[3,2-d]pyrimidin-4-ylamino)phenoxy]benzonitrile
CFAMM00393786 CHEMBL1921812 Bioactive N-[3-chloro-4-(3-chlorophenoxy)phenyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine
CFAMM00393785 CHEMBL1923003 Bioactive N-[3-chloro-4-(3-chlorophenoxy)phenyl]-5-methylpyrrolo[3,2-d]pyrimidin-4-amine
CFAMM00393784 CHEMBL1922898 Bioactive N-[3-chloro-4-(2-fluorophenoxy)phenyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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