CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM923
Family Name Renin and Cathepsin D inhibitor tert-butyl N-[(2R)-1-[[3-[[(2R,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-3-oxopropyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate family
No. of Seeds 19 No. of Other Members 4
Family Centroid CFAMM00317397 Functional Category Bioactive
Superfamily Renin and C-C chemokine receptor type 5 Binder Superfamily
Class Class 1170

Cousin Family NamesSeedsMembers
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Renin Inhibitor Remikiren Family 100 126
Renin Inhibitor Enalkiren Family 56 44
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Pol polyprotein inhibitor (2S)-N-[(2S,4S,5S)-4-hydroxy-5-[[(2S... 1 3
Pol polyprotein inhibitor AC1LAD48 family 19 5
Renin and Pepsin A inhibitor tert-butyl N-[(2S)-1-[[2-[[(4S,5S... 4 0
Renin and Pepsin A inhibitor [(2S)-1-[[(2R)-1-[[(2S,3R)-1-cycl... 2 2
Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-meth... 3 4
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5S)-5-(... 2 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Renin inhibitor (2S)-N-[(2S,3S)-1-cyclohexyl-3-hydroxy-5-(3-im... 4 0
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0
Renin inhibitor tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4... 2 2
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3
Renin inhibitor [(2S)-1-[[(2R)-1-[[(2S,3S)-1-cyclohexyl-3-hydr... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00317409 CHEMBL110553 Bioactive N-[(2S)-1-[[3-[[(2S,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-3-oxopropyl]amino]-1-oxo-3-phenylpropan-2-yl]morpholine-4-carboxamide
CFAMM00317389 CHEMBL111144 Bioactive N-[(2S)-1-[[3-[[(2S,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-3-oxopropyl]amino]-1-oxo-3-phenylpropan-2-yl]-4-(dimethylamino)piperidine-1-carboxamide
CFAMM00317408 CHEMBL1203094 Bioactive (2S,3S)-N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[[(3S,4S)-5-cyclohexyl-4-[[(2R)-3-[[(2S)-2-[4-(dimethylamino)butanoylamino]-3-phenylpropanoyl]amino]-2-methylpropanoyl]amino]-3-hydroxypentanoyl]amino]-3-methylpentanamide;dihydrochloride
CFAMM00317401 CHEMBL324624 Bioactive tert-butyl N-[(2S,3S)-6-[[(2S,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate
CFAMM00317394 CHEMBL112091 Bioactive tert-butyl N-[(2S,3S)-4-[2-[[(2S,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-2-oxoethyl]sulfanyl-3-hydroxy-1-phenylbutan-2-yl]carbamate
CFAMM00317407 CHEMBL1203095 Bioactive (2S,3S)-2-[[(3S,4S)-4-[3-[[(2S)-2-(6-aminohexanoylamino)-3-phenylpropanoyl]amino]propanoylamino]-5-cyclohexyl-3-hydroxypentanoyl]amino]-N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-3-methylpentanamide;dihydrochloride
CFAMM00317400 CHEMBL323006 Bioactive tert-butyl N-[(2S,3R)-6-[[(2S,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate
CFAMM00317393 CHEMBL320726 Bioactive 1-[[(2R)-1-[[3-[[(2S,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-3-oxopropyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]piperidine-4-carboxylic acid
CFAMM00317406 CHEMBL1203096 Bioactive (2S,3S)-2-[[(3S,4S)-4-[3-[[(2R)-2-[(3-amino-3-methylbutanoyl)amino]-3-phenylpropanoyl]amino]propanoylamino]-5-cyclohexyl-3-hydroxypentanoyl]amino]-N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-3-methylpentanamide;dihydrochloride
CFAMM00317399 CHEMBL109768 Bioactive tert-butyl N-[(2R)-1-[[2-[[(2R,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
CFAMM00317392 CHEMBL325329 Bioactive [4-[[(2S)-1-[[3-[[(2S,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-3-oxopropyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutyl]-trimethylazanium;chloride
CFAMM00317405 CHEMBL324692 Bioactive ethyl 1-[[(2S)-1-[[3-[[(2S,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-3-oxopropyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]piperidine-4-carboxylate
CFAMM00317398 CHEMBL324588 Bioactive tert-butyl N-[(2S)-4-[2-[[(2S,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-2-oxoethyl]sulfanyl-3-oxo-1-phenylbutan-2-yl]carbamate
CFAMM00317391 CHEMBL407882 Bioactive tert-butyl N-[1-[[(2S)-1-[[3-[[(2S,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-3-oxopropyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]piperidin-4-yl]carbamate
CFAMM00317404 CHEMBL325119 Bioactive tert-butyl N-[(2S)-6-[[(2S,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-3,6-dioxo-1-phenylhexan-2-yl]carbamate
CFAMM00317397 CHEMBL110060 Bioactive tert-butyl N-[(2R)-1-[[3-[[(2R,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-3-oxopropyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
CFAMM00317410 CHEMBL540047 Bioactive 4-amino-N-[(2S)-1-[[3-[[(2S,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-3-oxopropyl]amino]-1-oxo-3-phenylpropan-2-yl]piperidine-1-carboxamide;dihydrochloride
CFAMM00317390 CHEMBL113593 Bioactive tert-butyl N-[(2S,3R)-4-[2-[[(2S,3S)-5-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-2-oxoethyl]sulfanyl-3-hydroxy-1-phenylbutan-2-yl]carbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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