CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9230
Family Name C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloro-N-propan-2-ylpyrazine-2-carboxamide family
No. of Seeds 13 No. of Other Members 0
Family Centroid CFAMM00393836 Functional Category Bioactive
Superfamily Coagulation factor X and C-X-C chemokine receptor type 3 Binder Superfamily
Class Class 2337

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 16 295
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
XL-888 family 16 85
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
C-X-C chemokine receptor type 3 ligand 3-amino-6-chloro-5-[(3S... 11 1
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
C-C chemokine receptor type 5 ligand 6-chloro-2,4-dimethyl-N-[... 1 0
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated p... 3 7
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393828 CHEMBL1921885 Bioactive 5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-methylpyrazine-2-carboxamide
CFAMM00393834 CHEMBL1921877 Bioactive 5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-tert-butyl-6-chloropyrazine-2-carboxamide
CFAMM00393827 CHEMBL1921882 Bioactive 5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-(trifluoromethyl)pyrazine-2-carboxamide
CFAMM00393833 CHEMBL1921876 Bioactive 5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloropyrazine-2-carboxamide
CFAMM00393826 CHEMBL1921883 Bioactive 5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-methyl-6-(trifluoromethyl)pyrazine-2-carboxamide
CFAMM00393832 CHEMBL1921875 Bioactive 3-amino-5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloro-N-(2-hydroxyethyl)pyrazine-2-carboxamide
CFAMM00393825 CHEMBL1921880 Bioactive 5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloro-N-(2-hydroxyethyl)pyrazine-2-carboxamide
CFAMM00393831 CHEMBL1921886 Bioactive 5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N,6-dimethylpyrazine-2-carboxamide
CFAMM00393824 CHEMBL1921881 Bioactive 5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloro-N-[(2R)-2-hydroxypropyl]pyrazine-2-carboxamide
CFAMM00393830 CHEMBL1921887 Bioactive 5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-cyclopropyl-6-methylpyrazine-2-carboxamide
CFAMM00393836 CHEMBL1921879 Bioactive 5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloro-N-propan-2-ylpyrazine-2-carboxamide
CFAMM00393829 CHEMBL1921884 Bioactive 5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-cyclopropyl-6-(trifluoromethyl)pyrazine-2-carboxamide
CFAMM00393835 CHEMBL1921878 Bioactive 5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloro-N-cyclopropylpyrazine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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