CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9231
Family Name C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N,6-dimethylpyrazine-2-carboxamide family
No. of Seeds 6 No. of Other Members 0
Family Centroid CFAMM00393837 Functional Category Bioactive
Superfamily Coagulation factor X and C-X-C chemokine receptor type 3 Binder Superfamily
Class Class 2337

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 16 295
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
XL-888 family 16 85
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Cannabinoid receptor 1 Ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 18 41
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
C-X-C chemokine receptor type 3 ligand 3-amino-6-chloro-5-[(3S... 11 1
C-X-C chemokine receptor type 3 ligand 3-amino-6-chloro-5-[(3S... 2 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(2-amino-6... 13 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated p... 3 7
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393843 CHEMBL1921895 Bioactive 5-[(2R,5S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-5-ethyl-2-methylpiperazin-1-yl]-N,6-dimethylpyrazine-2-carboxamide
CFAMM00393842 CHEMBL1921896 Bioactive 5-[(2R,5S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-5-ethyl-2-methylpiperazin-1-yl]-N-cyclopropyl-6-methylpyrazine-2-carboxamide
CFAMM00393841 CHEMBL1921891 Bioactive 5-[(3S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-cyclopropyl-6-methylpyrazine-2-carboxamide
CFAMM00393840 CHEMBL1921890 Bioactive 5-[(3S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-ethyl-6-methylpyrazine-2-carboxamide
CFAMM00393839 CHEMBL1921892 Bioactive 5-[(2R,5S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-5-ethyl-2-methylpiperazin-1-yl]-6-methylpyrazine-2-carboxamide
CFAMM00393837 CHEMBL1921889 Bioactive 5-[(3S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N,6-dimethylpyrazine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27256 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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