CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9248
Family Name Serine/threonine-protein kinase RIO2 and Serine/threonine-protein kinase RIO1 inhibitor N-[(3-methoxyphenyl)methyl]-N-methyl-6-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide family
No. of Seeds 12 No. of Other Members 13
Family Centroid CFAMM00375678 Functional Category Bioactive
Superfamily Insulin-like growth factor 1 receptor and Tyrosine-protein kinase JAK2 Binder Superfamily
Class Class 974

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
DCC-2036 family 2 5
Smoothened homolog Inhibitor LDE225 Family 3 76
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Adenosine receptor A2b Ligand CVT-6694 Family 1 22
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 19 40
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 7
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YLX fa... 3 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
DNA gyrase subunit B inhibitor N-ethyl-5-[6-methoxy-5-(2-oxo-3... 3 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 18
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase SYK and Cytochrome P450 2D6 inhibitor ... 3 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 1 1
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 0
5-hydroxytryptamine receptor 6 ligand 2-[(2Z)-2-[3-[(3-methoxy... 1 11
Adenosine receptor A2b and Adenosine receptor A1 ligand N-(3,4... 1 8
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Coagulation factor X inhibitor SureCN5641901 family 5 0
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 1 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 3
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Adenosine receptor A2b and Adenosine receptor A1 ligand N-[(3Z... 2 2
Adenosine receptor A2b and Adenosine receptor A1 ligand 8-[1-[... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393951 CHEMBL1922035 Bioactive N-[(3-methoxyphenyl)methyl]-1-methyl-6-(1H-pyrazol-4-yl)pyrrolo[2,3-b]pyridine-2-carboxamide
CFAMM00393950 CHEMBL1922136 Bioactive AGN-PC-0BTJUA
CFAMM00393947 CHEMBL1923181 Bioactive N-[(1R)-1-(3-methoxyphenyl)ethyl]-6-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27163 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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