CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9257
Family Name Melanin-concentrating hormone receptor 1 and Melanin-concentrating hormone receptor 1 ligand (4aR,11R,11aS)-11-methyl-2-[3-(oxan-4-yl)propyl]-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazole family
No. of Seeds 5 No. of Other Members 6
Family Centroid CFAMM00129379 Functional Category Bioactive with Natural Product
Superfamily Melanin-concentrating hormone receptor 1 and Melanin-concentrating hormone receptor 2 Binder Superfamily 2
Class Class 173

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
Melanin-concentrating hormone receptor 1 Ligand Amg 076 Family 2 8
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Cannabinoid receptor 2 ligand 1-[[4-[5-fluoro-6-(piperidin-1-y... 21 2
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Capsid scaffolding protein inhibitor AC1O583J family 5 1
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 1 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393972 CHEMBL1922269 Bioactive (4aR,11R,11aS)-11-methyl-2-[2-(oxan-4-yl)ethyl]-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazole
CFAMM00393971 CHEMBL1922268 Bioactive 4-[2-[(4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazol-2-yl]ethyl]morpholin-3-one
CFAMM00393975 CHEMBL1922262 Bioactive 4-[2-[(4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazol-2-yl]ethyl]morpholine
CFAMM00393968 CHEMBL1922271 Bioactive (4aR,11R,11aS)-11-methyl-2-[4-(oxan-4-yl)butyl]-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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