CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9258
Family Name Hepatocyte growth factor receptor ligand 5-[(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]-2H-isoquinolin-1-one family
No. of Seeds 6 No. of Other Members 2
Family Centroid CFAMM00393979 Functional Category Bioactive
Superfamily Hepatocyte growth factor receptor and Type-1 angiotensin II receptor Binder Superfamily
Class Class 2684

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
PHA848125 family 13 138
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... 6 37
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 2
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 ligand AGN-PC-07N4XX family 6 10
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Smoothened homolog inhibitor SureCN1091571 family 2 2
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Aurora kinase A inhibitor AGN-PC-00EHLC family 1 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Prothrombin inhibitor AGN-PC-09QLAK family 10 2
TGF-beta receptor type-1 ligand 3-[[3-(6-methylpyridin-2-yl)-4... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Hepatocyte growth factor receptor ligand 5-[(6-thiophen-3-yl-[... 1 1
Hepatocyte growth factor receptor ligand 5-[[6-(3-hydroxypheny... 2 0
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-3-... 13 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
P2X purinoceptor 7 inhibitor SureCN9931311 family 2 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Histone deacetylase 1 and Proto-oncogene tyrosine-protein kina... 4 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00393983 CHEMBL1922416 Bioactive 5-[[6-(3-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]-2H-isoquinolin-1-one
CFAMM00393982 CHEMBL1922417 Bioactive 5-[[6-(3-nitrophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]-2H-isoquinolin-1-one
CFAMM00393986 CHEMBL1922418 Bioactive 3-[3-[(1-oxo-2H-isoquinolin-5-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]benzonitrile
CFAMM00393979 CHEMBL1922405 Bioactive 5-[(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]-2H-isoquinolin-1-one
CFAMM00393985 CHEMBL1922414 Bioactive 5-[[6-(2-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]-2H-isoquinolin-1-one
CFAMM00393984 CHEMBL1922415 Bioactive 5-[[6-(3-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]-2H-isoquinolin-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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