CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9272
Family Name Receptor tyrosine-protein kinase erbB-2 ligand 2-[2-[4-[3-chloro-4-(3-chlorophenoxy)anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy]ethanol family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00394113 Functional Category Bioactive
Superfamily Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Superfamily
Class Class 1049

Cousin Family NamesSeedsMembers
Nuclear factor NF-kappa-B p100 subunit Inhibitor GMX1777 Family 3 7
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Varlitinib family 2 8
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Oxytocin receptor and Vasopressin V1a receptor Ligand PF-32741... 4 36
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Vascular endothelial growth factor receptor 2 and Fibroblast g... 3 11
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-a... 11 13
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Corticotropin-releasing factor receptor 1 ligand N-butyl-9-(2-... 4 5
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Hepatocyte growth factor receptor ligand [3,5-dichloro-4-[4-(3... 1 1
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 3
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 2 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 14 3
Glucagon receptor ligand SureCN2647807 family 3 7
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 0
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJ2 family 1 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00394111 CHEMBL1923006 Bioactive 2-[4-[3-chloro-4-(3-chlorophenoxy)anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethanol
CFAMM00394115 CHEMBL1923011 Bioactive 2-[2-[4-[3-chloro-4-[3-(trifluoromethoxy)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy]ethanol
CFAMM00394114 CHEMBL2322330 Bioactive 1-[3-[2-chloro-4-[[5-[2-(2-hydroxyethoxy)ethyl]pyrrolo[3,2-d]pyrimidin-4-yl]amino]phenoxy]phenyl]-3-cyclohexylurea
CFAMM00394113 CHEMBL1923009 Bioactive 2-[2-[4-[3-chloro-4-(3-chlorophenoxy)anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy]ethanol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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