CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9288
Family Name cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A inhibitor N-ethyl-1-(2-methoxyphenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide family
No. of Seeds 3 No. of Other Members 10
Family Centroid CFAMM00351391 Functional Category Bioactive
Superfamily Survival motor neuron protein and Cruzipain Binder Superfamily 2
Class Class 3548

Cousin Family NamesSeedsMembers
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
BIBT986 family 7 96
DCC-2036 family 2 5
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
PHA848125 family 13 138
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 7
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Smoothened homolog inhibitor SureCN1091571 family 2 2
Mitogen-activated protein kinase 14 inhibitor DEL-B, 14b family 2 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 5
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Serine/threonine-protein kinase Chk2 inhibitor SureCN3919556 f... 4 8
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Mitogen-activated protein kinase 10 and Transcription factor A... 1 1
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Vascular endothelial growth factor receptor 1 and Vascular end... 11 38
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Hepatocyte growth factor receptor ligand 5-[[6-(3-hydroxypheny... 2 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-chloro-4-(4-methyl... 2 1
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
Prothrombin and Coagulation factor X inhibitor SureCN6929748 f... 6 5
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 29
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YLX fa... 3 1
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 3 2
Type-1 angiotensin II receptor ligand 7-methyl-N-(2-phenylethy... 2 10
Type-1 angiotensin II receptor ligand N-[2-(3-methoxyphenyl)et... 2 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Cyclin-dependent kinase 2 and Serine/threonine-protein kinase ... 2 2
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Coagulation factor X inhibitor AGN-PC-07C10A family 3 2
Renin inhibitor AGN-PC-073MLF family 7 6
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-[2-... 5 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Melanocortin receptor 4 ligand AGN-PC-076AMT family 2 9
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Hepatocyte growth factor receptor ligand AGN-PC-00AG7Q family 1 10
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN136... 1 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Coagulation factor X inhibitor SureCN5641901 family 5 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07C5JC family 1 3
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00394241 CHEMBL1923571 Bioactive [4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]-morpholin-4-ylmethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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