CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9289
Family Name Tyrosine-protein kinase JAK2 inhibitor N-[2-[2-[3-chloro-4-(4-methylpiperazin-1-yl)anilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00394247 Functional Category Bioactive
Superfamily Tyrosine-protein kinase JAK2 and Aurora kinase A Binder Superfamily
Class Class 712

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK2 and ALK tyrosine kinase receptor ... 5 0
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Adenosine receptor A2a and Adenosine receptor A2b ligand 6-(2,... 6 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-0CSEAG family 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00394248 CHEMBL1923587 Bioactive N-tert-butyl-3-[2-[3-chloro-4-(4-methylpiperazin-1-yl)anilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]benzenesulfonamide
CFAMM00394247 CHEMBL1923582 Bioactive N-[2-[2-[3-chloro-4-(4-methylpiperazin-1-yl)anilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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