CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9290
Family Name Tyrosine-protein kinase JAK2 inhibitor N-[3-chloro-4-(4-methylpiperazin-1-yl)phenyl]-7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-amine family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00394250 Functional Category Bioactive
Superfamily Hepatocyte growth factor receptor Ligand Amg 208 Superfamily
Class Class 1248

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Heat shock protein HSP 90-alpha inhibitor 3-[2-amino-4-chloro-... 7 2
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Mitogen-activated protein kinase 10 and Transcription factor A... 1 1
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 7 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-[2-... 5 0
Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 14 3
Glucagon receptor ligand SureCN2647807 family 3 7
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN136... 1 0
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3


External ID

Functional Category

Molecule Name

CFAMM00394251 CHEMBL1923590 Bioactive N-[3-chloro-4-(4-methylpiperazin-1-yl)phenyl]-7-(6-methoxypyridin-3-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine
CFAMM00394250 CHEMBL1923584 Bioactive N-[3-chloro-4-(4-methylpiperazin-1-yl)phenyl]-7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-amine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

Last update by



89101 visits since 2014 .........


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links


Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543