CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9294
Family Name Histamine H3 receptor ligand 1-methyl-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridin-2-one family
No. of Seeds 5 No. of Other Members 5
Family Centroid CFAMM00394267 Functional Category Bioactive with Natural Product
Superfamily Irdabisant Superfamily
Class Class 1211

Cousin Family NamesSeedsMembers
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Irdabisant family 49 53
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Cellular tumor antigen p53 and Lysine-specific demethylase 4E ... 1 5
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 4
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Histamine H1 receptor and Histamine H3 receptor ligand 4-[(4-m... 3 6
Histamine H3 receptor ligand SureCN1373218 family 2 2
Histamine H3 receptor ligand 6-[3-chloro-4-[3-[(2R)-2-methylpy... 1 0
Histamine H3 receptor ligand 2-methyl-4-[4-(3-pyrrolidin-1-ylp... 4 1
Histamine H3 receptor ligand 3-methyl-1-[4-(3-piperidin-1-ylpr... 6 1
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
Histamine H3 receptor ligand (4R)-3-[4-(1-cyclobutylpiperidin-... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 7 13
5-hydroxytryptamine receptor 3A ligand 5-[4-[3-(azepan-1-yl)pr... 2 0
Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-07CR9C ... 10 7
Metabotropic glutamate receptor 2 ligand 4-(3-chloro-4-cyclope... 1 3
Histamine H3 receptor ligand (E)-1-[(2S)-2-(pyrrolidin-1-ylmet... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00394267 CHEMBL1923729 Bioactive 1-methyl-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridin-2-one
CFAMM00394272 CHEMBL1923736 Bioactive 1-methyl-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-2-oxopyridine-3-carbonitrile
CFAMM00394271 CHEMBL1923735 Bioactive 1-benzyl-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42616 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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