CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9295
Family Name Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1-phenylpyridin-2-one family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00185092 Functional Category Bioactive
Superfamily Histamine H3 receptor and Survival motor neuron protein Binder Superfamily 2
Class Class 3662

Cousin Family NamesSeedsMembers
Irdabisant family 49 53
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Histamine H3 receptor Ligand A-349821 Family 49 228
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 10
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Neuropeptide S receptor and Survival motor neuron protein liga... 1 2
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Melanin-concentrating hormone receptor 1 ligand 1-[1-(1-methyl... 5 10
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Histamine H3 receptor ligand SureCN1373218 family 2 2
Histamine H3 receptor ligand 1-methyl-5-[4-[3-[(2R)-2-methylpy... 5 5
Translocator protein inhibitor [11C]DAA1106 family 15 2
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
C-C chemokine receptor type 5 ligand dimethyl-[[4-[[7-(4-methy... 7 8
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
Histamine H3 receptor ligand SureCN3057839 family 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-07CR9C ... 10 7
Amyloid beta A4 protein inhibitor 2-(fluoranylmethyl)-3-[4-[(E... 1 3
Sphingosine 1-phosphate receptor 3 and Sphingosine 1-phosphate... 3 9
Sphingosine 1-phosphate receptor 3 and Sphingosine 1-phosphate... 2 1
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 1 1
Integrin beta-1 and Integrin alpha-5 inhibitor 3-[[(2R)-2-(4-a... 1 1
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-04F7M... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00394275 CHEMBL1923734 Bioactive 1-(4-fluorophenyl)-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543