CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9307
Family Name Cystic fibrosis transmembrane conductance regulator inhibitor (3S)-N-(4-pentylphenyl)-2-(4-propan-2-yloxypyridine-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00394359 Functional Category Bioactive
Superfamily Peptidyl-prolyl cis-trans isomerase FKBP1A and Collagenase 3 Binder Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
DCC-2036 family 2 5
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
C-C chemokine receptor type 5 ligand 6-cyano-N-[(3R)-3-[4-[N-[... 3 0
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 2 7
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 4 3
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 1 3
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00394361 CHEMBL195630 Bioactive SureCN3934783
CFAMM00394359 CHEMBL192547 Bioactive (3S)-N-(4-pentylphenyl)-2-(4-propan-2-yloxypyridine-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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