CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9316
Family Name C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N-[(4-methylpyridin-3-yl)methyl]anilino]piperidin-1-yl]butyl]-2,4-dimethylpyridine-3-carboxamide family
No. of Seeds 13 No. of Other Members 1
Family Centroid CFAMM00394465 Functional Category Bioactive
Superfamily C-C chemokine receptor type 5 and Cruzipain Binder Superfamily
Class Class 297

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
DCC-2036 family 2 5
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Integrin beta-3 Inhibitor L-756568 Family 8 59
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Reverse transcriptase Inhibitor Atevirdine Family 4 55
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-[3... 1 2
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 2 0
C-C chemokine receptor type 5 ligand (2,4-dimethyl-1-oxidopyri... 5 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 1 0
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Histamine H3 receptor and Cytochrome P450 3A4 ligand SureCN822... 3 7
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 10 15
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 13
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
C-C chemokine receptor type 5 ligand 3,5-dichloro-N-[3-[4-[N-[... 2 6
C-C chemokine receptor type 5 ligand 6-cyano-N-[(3R)-3-[4-[N-[... 3 0
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 3 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 1 1
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 10 13
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-(cy... 3 2
Motilin receptor ligand SureCN2768193 family 2 1
Motilin receptor ligand SureCN2765637 family 1 1
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Transient receptor potential cation channel subfamily V member... 6 1
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Coagulation factor X inhibitor 3-Oxybenzamide 48 family 1 12
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 6 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Acyl-CoA desaturase inhibitor 3-[[2-[4-(2-chlorophenoxy)piperi... 8 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Macrophage colony-stimulating factor 1 receptor ligand 4-[3-ch... 1 0
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 1
NP N-(2-(3,4-dimethoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinami... 6 1
NP N-(2-(2-methoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinamide F... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00394462 CHEMBL1926899 Bioactive 5-N-[(3R)-3-[4-[4-methoxy-N-[(4-methylpyridin-3-yl)methyl]anilino]piperidin-1-yl]butyl]-4,6-dimethyl-2-N-propan-2-ylpyridine-2,5-dicarboxamide
CFAMM00394468 CHEMBL1926894 Bioactive 6-chloro-N-[(3R)-3-[4-[4-methoxy-N-(pyridin-3-ylmethyl)anilino]piperidin-1-yl]butyl]-2,4-dimethylpyridine-3-carboxamide
CFAMM00394467 CHEMBL1926896 Bioactive 6-fluoro-N-[(3R)-3-[4-[4-methoxy-N-[(4-methylpyridin-3-yl)methyl]anilino]piperidin-1-yl]butyl]-2,4-dimethylpyridine-3-carboxamide
CFAMM00394460 CHEMBL1926902 Bioactive 6-fluoro-N-[(3R)-3-[4-[4-(2-methoxyethoxy)-N-[(4-methylpyridin-3-yl)methyl]anilino]piperidin-1-yl]butyl]-2,4-dimethylpyridine-3-carboxamide
CFAMM00394466 CHEMBL1926897 Bioactive 6-fluoro-N-[(3R)-3-[4-[4-methoxy-N-(pyridin-3-ylmethyl)anilino]piperidin-1-yl]butyl]-2,4-dimethylpyridine-3-carboxamide
CFAMM00394459 CHEMBL1926900 Bioactive 6-chloro-N-[(3R)-3-[4-[4-(2-methoxyethoxy)-N-[(4-methylpyridin-3-yl)methyl]anilino]piperidin-1-yl]butyl]-2,4-dimethylpyridine-3-carboxamide
CFAMM00394465 CHEMBL1926890 Bioactive N-[(3R)-3-[4-[4-methoxy-N-[(4-methylpyridin-3-yl)methyl]anilino]piperidin-1-yl]butyl]-2,4-dimethylpyridine-3-carboxamide
CFAMM00394458 CHEMBL1926901 Bioactive 6-cyano-N-[(3R)-3-[4-[4-(2-methoxyethoxy)-N-[(4-methylpyridin-3-yl)methyl]anilino]piperidin-1-yl]butyl]-2,4-dimethylpyridine-3-carboxamide
CFAMM00394464 CHEMBL1926891 Bioactive 2-chloro-N-[(3R)-3-[4-[4-methoxy-N-[(4-methylpyridin-3-yl)methyl]anilino]piperidin-1-yl]butyl]-4-methylpyridine-3-carboxamide
CFAMM00394457 CHEMBL1926904 Bioactive N-[(3R)-3-[4-[4-(2-amino-2-oxoethoxy)-N-[(4-methylpyridin-3-yl)methyl]anilino]piperidin-1-yl]butyl]-6-cyano-2,4-dimethylpyridine-3-carboxamide
CFAMM00394463 CHEMBL1926898 Bioactive 6-cyano-N-[(3R)-3-[4-[4-methoxy-N-[(4-methylpyridin-3-yl)methyl]anilino]piperidin-1-yl]butyl]-2,4-dimethylpyridine-3-carboxamide
CFAMM00394456 CHEMBL1926889 Bioactive N-[(3R)-3-[4-[4-methoxy-N-[(4-methylpyridin-3-yl)methyl]anilino]piperidin-1-yl]butyl]-3,5-dimethylpyridine-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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