CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9383
Family Name Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL194659 family
No. of Seeds 5 No. of Other Members 5
Family Centroid CFAMM00394910 Functional Category Bioactive
Superfamily Transporter and Alpha-2C adrenergic receptor Binder Superfamily
Class Class 280

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Estrogen receptor and Estrogen receptor beta ligand (2R,3R,4S)... 3 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Sodium-dependent serotonin transporter inhibitor AGN-PC-078ZCU... 1 0
Synaptic vesicular amine transporter inhibitor (2R)-3-[(2R,5S)... 1 1


External ID

Functional Category

Molecule Name

CFAMM00394909 CHEMBL365101 Bioactive CHEMBL365101
CFAMM00394908 CHEMBL195706 Bioactive CHEMBL195706
CFAMM00394914 CHEMBL197135 Bioactive CHEMBL197135
CFAMM00394913 CHEMBL193435 Bioactive CHEMBL193435
CFAMM00394910 CHEMBL194659 Bioactive CHEMBL194659

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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