CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9393
Family Name Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family
No. of Seeds 7 No. of Other Members 2
Family Centroid CFAMM00395010 Functional Category Bioactive
Superfamily Poly [ADP-ribose] polymerase 1 and Serine/threonine-protein kinase Chk1 Binder Superfamily 2
Class Class 929

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
High affinity nerve growth factor receptor Ligand Lestaurtinib... 6 126
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
B-lymphocyte antigen CD20 Inhibitor Rituxan Immunology Family 10 17
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Setipiprant family 5 118
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Vascular endothelial growth factor receptor 2 Ligand Isoindoli... 11 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Serine/threonine-protein kinase Chk1 Inhibitor BIS-IMIDE A Family 1 3
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Kinesin-like protein KIF11 Inhibitor Methyl 7-tert-butyl-9h-ca... 2 9
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
Calcitonin gene-related peptide type 1 receptor ligand CHEMBL1... 5 8
Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydr... 2 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 3 4
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Aurora kinase A and Aurora kinase B inhibitor SureCN3802769 fa... 2 20
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
ALK tyrosine kinase receptor and Insulin receptor ligand 9-eth... 9 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 4 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Prostaglandin D2 receptor 2 ligand 2-[(3R)-3-(3,3-diphenylprop... 1 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
High affinity nerve growth factor receptor ligand CHEMBL254555... 2 2
Protein kinase C alpha type and Protein kinase C delta type in... 2 0
Cyclin-dependent kinase 2 and Vascular endothelial growth fact... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Mitogen-activated protein kinase kinase kinase 11 and Mitogen-... 1 1
Translocator protein inhibitor CHEMBL1672413 family 1 2
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
Kinesin-like protein KIF11 inhibitor 9-(trifluoromethyl)-1,2,4... 4 1
Vascular endothelial growth factor receptor 2 ligand 3-[2-[(Z)... 1 3
Glycogen synthase kinase 3 beta and Dual specificity tyrosine-... 1 6
Potassium voltage-gated channel subfamily A member 5 ligand 3-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00395013 CHEMBL1935274 Bioactive CHEMBL1935274
CFAMM00395006 CHEMBL1935268 Bioactive CHEMBL1935268
CFAMM00395012 CHEMBL1935272 Bioactive CHEMBL1935272
CFAMM00395011 CHEMBL1935273 Bioactive CHEMBL1935273
CFAMM00395010 CHEMBL1935258 Bioactive CHEMBL1935258
CFAMM00395008 CHEMBL1935262 Bioactive CHEMBL1935262
CFAMM00395007 CHEMBL1935261 Bioactive CHEMBL1935261

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23968 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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