CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9395
Family Name Macrophage metalloelastase inhibitor (2S)-3-methyl-2-[[8-[3-(trifluoromethyl)pyrazol-1-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid family
No. of Seeds 2 No. of Other Members 6
Family Centroid CFAMM00395020 Functional Category Bioactive with Natural Product
Superfamily Macrophage metalloelastase and Prostaglandin G/H synthase 2 Binder Superfamily
Class Class 3238

Cousin Family NamesSeedsMembers
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
Apricoxib family 8 77
Indeglitazar family 3 39
Integrin beta-3 Inhibitor L-756568 Family 8 59
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Arachidonate 15-lipoxygenase inhibitor AGN-PC-04S2WZ family 4 9
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Collagenase 3 and A disintegrin and metalloproteinase with thr... 5 6
Macrophage metalloelastase inhibitor (2S)-3-methyl-2-[[8-(1H-p... 1 0
Macrophage metalloelastase and Matrix metalloproteinase-12 inh... 2 1
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 0


External ID

Functional Category

Molecule Name

CFAMM00395020 CHEMBL1935280 Bioactive (2S)-3-methyl-2-[[8-[3-(trifluoromethyl)pyrazol-1-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid
CFAMM00395027 CHEMBL1935290 Bioactive (2S)-3-methyl-2-[[8-(1H-pyrrol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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