CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-3-hydroxy-6-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-[(4-methylphenyl)methyl]-6-oxo-1-phenylhexan-2-yl]carbamate family
No. of Seeds 40 No. of Other Members 29
Family Centroid CFAMM00307081 Functional Category Bioactive
Superfamily Pol polyprotein and Disintegrin Binder Superfamily
Class Class 3076

Cousin Family NamesSeedsMembers
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Plasmepsin-2 Inhibitor KNI-10232 Family 8 36
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-3-hydroxy-6... 11 8
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Pol polyprotein inhibitor AC1L9R8S family 5 4
Pol polyprotein inhibitor (2R,3R,4R,5R)-3,4-dihydroxy-N-[(2S)-... 22 10
Beta-secretase 1 and Cathepsin D inhibitor (1R,3S)-N-[(2S,3S)-... 2 25
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Pol polyprotein inhibitor (2S)-4-benzyl-1-[(2S,4R)-4-benzyl-2-... 10 4
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 4
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Pol polyprotein inhibitor (2R)-2-benzyl-5-[(3S,5R)-3-benzyl-5-... 11 5
Pol polyprotein inhibitor 3-[[(3S,5R)-5-benzyl-1-[(2S,4R)-4-be... 4 0
Pol polyprotein inhibitor (2R,4S)-5-[(5R)-3-[(3-aminophenyl)me... 4 2
Pol polyprotein inhibitor AC1LADII family 12 1
Beta-secretase 1 inhibitor (2S)-2-[(3R)-3-acetamido-3-(2-methy... 3 0
Pol polyprotein inhibitor SureCN3530080 family 3 8
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-5-benzyl-3-... 3 0
Pol polyprotein inhibitor L-689,502 family 17 2
Pol polyprotein inhibitor SDZ PRI 053 family 8 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 4
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5S)-3-hydroxy-5... 4 12
Pol polyprotein inhibitor AC1NS2O6 family 3 0
Pol polyprotein inhibitor AC1L9R8I family 1 0
Pol polyprotein inhibitor AC1L9R8M family 4 1
Pol polyprotein inhibitor AC1LA3C0 family 2 18
Pol polyprotein inhibitor (3S,5R)-1-[(2S,4R)-6-amino-4-benzyl-... 1 0
Pol polyprotein inhibitor (2R,3R,4R,5R)-2,5-bis[(2-fluoropheny... 4 0
Pol polyprotein inhibitor Diol-Based HIV-1 protease inhibitor ... 1 0
Pol polyprotein inhibitor (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5... 2 0
Pol polyprotein inhibitor AC1LAKSR family 1 0
Pol polyprotein inhibitor (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopy... 3 0
Pol polyprotein inhibitor AC1LADB2 family 1 0
Pol polyprotein inhibitor SureCN3527634 family 1 0
Pol polyprotein inhibitor (2R,4S)-2-benzyl-5-[2-(tert-butylsul... 1 0
Pol polyprotein inhibitor methyl (2S)-2-[[(2R,4S,5S)-2-benzyl-... 1 1


External ID

Functional Category

Molecule Name

CFAMM00307109 CHEMBL418986 Bioactive tert-butyl N-[(E,2S,3S,5R)-3-hydroxy-5-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl]-1,8-diphenyloct-7-en-2-yl]carbamate
CFAMM00307076 CHEMBL49544 Bioactive SureCN7336968
CFAMM00307056 CHEMBL47514 Bioactive AC1L9R8R
CFAMM00307049 CHEMBL101560 Bioactive 145631-04-5
CFAMM00307062 CHEMBL2062160 Bioactive AC1LALHQ
CFAMM00307075 CHEMBL49768 Bioactive SureCN7340371
CFAMM00307088 CHEMBL46061 Bioactive tert-butyl N-[(2S,3S,5R)-5-[[4-[(dimethylamino)methyl]phenyl]methyl]-3-hydroxy-6-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-6-oxo-1-phenylhexan-2-yl]carbamate
CFAMM00307101 CHEMBL297620 Bioactive AC1L9R8P
CFAMM00307114 CHEMBL319408 Bioactive 145631-03-4
CFAMM00307081 CHEMBL103821 Bioactive tert-butyl N-[(2S,3S,5R)-3-hydroxy-6-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-[(4-methylphenyl)methyl]-6-oxo-1-phenylhexan-2-yl]carbamate
CFAMM00307094 CHEMBL319092 Bioactive 145680-03-1
CFAMM00307048 CHEMBL108960 Bioactive AC1LALHH
CFAMM00307074 CHEMBL263938 Bioactive tert-butyl N-[(2S,3S,5R)-3-hydroxy-6-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-6-oxo-1-phenyl-5-[[4-(trifluoromethyl)phenyl]methyl]hexan-2-yl]carbamate
CFAMM00307087 CHEMBL44489 Bioactive AC1L9R8Z
CFAMM00307106 CHEMBL297294 Bioactive AC1L9R92
CFAMM00307093 CHEMBL308780 Bioactive tert-butyl N-[(2R,5S)-5-benzyl-3-hydroxy-6-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-6-oxo-1-phenylhexan-2-yl]carbamate
CFAMM00307060 CHEMBL416814 Bioactive SureCN7331375
CFAMM00307073 CHEMBL296137 Bioactive AC1L9R8K
CFAMM00307053 CHEMBL318003 Bioactive tert-butyl N-[(2S,3S,5R)-5-benzyl-3-hydroxy-6-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-6-oxo-1-phenylhexan-2-yl]carbamate
CFAMM00307112 CHEMBL296115 Bioactive L-685434
CFAMM00307066 CHEMBL433072 Bioactive AC1L9R99
CFAMM00307079 CHEMBL295924 Bioactive Hydroxyethylene dipeptide isostere 25
CFAMM00307105 CHEMBL265516 Bioactive AC1L9R8O
CFAMM00307059 CHEMBL319417 Bioactive tert-butyl N-[(2S,3S,5R)-5-[(4-tert-butylphenyl)methyl]-3-hydroxy-6-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-6-oxo-1-phenylhexan-2-yl]carbamate
CFAMM00307085 CHEMBL299821 Bioactive SureCN7335696
CFAMM00307098 CHEMBL45928 Bioactive SureCN7339564
CFAMM00307052 CHEMBL430469 Bioactive 145631-05-6
CFAMM00307065 CHEMBL21041 Bioactive tert-butyl N-[(2S,3S,5R)-6-[[(2R,3R)-3-amino-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate
CFAMM00307104 CHEMBL98885 Bioactive Urethane deriv. 7
CFAMM00307058 CHEMBL295777 Bioactive AC1L9R98
CFAMM00307071 CHEMBL297066 Bioactive AC1L9R90
CFAMM00307084 CHEMBL296855 Bioactive AC1L9R8L
CFAMM00307097 CHEMBL46114 Bioactive AC1L9R8X
CFAMM00307110 CHEMBL420466 Bioactive tert-butyl N-[(2S,3S,5R)-3-hydroxy-6-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-[(4-iodophenyl)methyl]-6-oxo-1-phenylhexan-2-yl]carbamate
CFAMM00307077 CHEMBL291196 Bioactive AC1L9R8Y
CFAMM00307090 CHEMBL319792 Bioactive 145680-04-2
CFAMM00307064 CHEMBL296484 Bioactive AC1L9R8Q
CFAMM00307103 CHEMBL320150 Bioactive tert-butyl N-[(2S,3S,5R)-5-benzyl-3-hydroxy-6-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-methyl-6-oxo-1-phenylhexan-2-yl]carbamate
CFAMM00307057 CHEMBL265514 Bioactive AC1NS2JR
CFAMM00307096 CHEMBL322634 Bioactive tert-butyl N-[(2S,3S,5R)-3-hydroxy-6-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-6-oxo-5-[(2,3,4,5,6-pentafluorophenyl)methyl]-1-phenylhexan-2-yl]carbamate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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