CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Aromatase inhibitor (3R,4R)-4-benzyl-3-[(3-hydroxyphenyl)methyl]oxolan-2-one family
No. of Seeds 1 No. of Other Members 10
Family Centroid CFAMM00317575 Functional Category Bioactive with Natural Product
Superfamily Aromatase and Cannabinoid receptor 2 Binder Superfamily
Class Class 2550

Cousin Family NamesSeedsMembers
Oestrogen receptor ligand Dienestrol Family 35 440
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Mitogen-activated protein kinase 12 Inhibitor SCIO-469 Family 1 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
DNA polymerase Inhibitor 3alpha-o-trans-p-coumaroyl-7-labden-1... 1 13
Prelamin-A/C inhibitor CHEMBL1495780 family 1 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Thromboxane A2 receptor ligand AGN-PC-003UTI family 1 0
Free fatty acid receptor 1 ligand 3-[4-[2-[3-(trifluoromethoxy... 1 0
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Glutamate carboxypeptidase 2 inhibitor 2-[(3-hydroxyphenyl)met... 1 0
Putative NP ZINC03197541 Family 1 0
2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-dicarboxylate NP ZINC0... 1 0


External ID

Functional Category

Molecule Name

CFAMM00317575 CHEMBL1094154 Bioactive (3R,4R)-4-benzyl-3-[(3-hydroxyphenyl)methyl]oxolan-2-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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