CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9402
Family Name Histamine H3 receptor ligand 1'-cyclobutyl-6-(1-ethylsulfonylpiperidin-4-yl)oxyspiro[3,4-dihydrochromene-2,4'-piperidine] family
No. of Seeds 7 No. of Other Members 10
Family Centroid CFAMM00395076 Functional Category Bioactive
Superfamily Histamine H3 receptor Binder Superfamily 7
Class Class 142

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Histamine H3 receptor ligand 1-[4-(1'-cyclobutylspiro[3,4-dihy... 4 0


External ID

Functional Category

Molecule Name

CFAMM00395073 CHEMBL1935425 Bioactive 4-(1'-cyclobutylspiro[3,4-dihydrochromene-2,4'-piperidine]-6-yl)oxythiane 1,1-dioxide
CFAMM00395071 CHEMBL2013049 Bioactive 1'-cyclobutyl-6-(1-propan-2-ylsulfonylpiperidin-4-yl)oxyspiro[3,4-dihydrochromene-2,4'-piperidine]
CFAMM00395077 CHEMBL2013045 Bioactive 1'-cyclobutyl-6-(1-methylsulfonylpiperidin-4-yl)oxyspiro[3,4-dihydrochromene-2,4'-piperidine]
CFAMM00395070 CHEMBL1935426 Bioactive 4-[(1'-cyclobutylspiro[3,4-dihydrochromene-2,4'-piperidine]-6-yl)oxymethyl]thiane 1,1-dioxide
CFAMM00395076 CHEMBL2013044 Bioactive 1'-cyclobutyl-6-(1-ethylsulfonylpiperidin-4-yl)oxyspiro[3,4-dihydrochromene-2,4'-piperidine]
CFAMM00395063 CHEMBL1935416 Bioactive 1'-cyclobutyl-6-(3-methylsulfonylpropoxy)spiro[3,4-dihydrochromene-2,4'-piperidine]
CFAMM00395068 CHEMBL2013050 Bioactive 1'-cyclobutyl-6-(1-cyclopropylsulfonylpiperidin-4-yl)oxyspiro[3,4-dihydrochromene-2,4'-piperidine]

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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