CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9407
Family Name C-C chemokine receptor type 3 and Sodium-dependent serotonin transporter ligand SureCN6773342 family
No. of Seeds 12 No. of Other Members 2
Family Centroid CFAMM00048930 Functional Category Bioactive
Superfamily Alpha adrenergic receptor Ligand Droperidol Superfamily
Class Class 252

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
Mu-type opioid receptor Ligand Fentanyl Family 9 647
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
K-604 family 4 71
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZFJZ family 1 3
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 8
Progesterone receptor and Androgen receptor ligand AGN-PC-080P... 4 27
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
C-C chemokine receptor type 3 ligand SureCN6704607 family 3 22
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Pol polyprotein inhibitor 3-[(4R,5R,6R)-4-benzyl-3-(3-carbamoy... 3 1
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 0
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Bifunctional epoxide hydrolase 2 inhibitor 1-(3-acetylphenyl)-... 1 3
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-[[(2-hydroxy... 6 2
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Phospholipase D1 and Phospholipase D2 inhibitor 4-bromo-N-[(2S... 1 2
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Proteinase-activated receptor 1 ligand 2-[[2-[[2-[acetyl-[(E)-... 6 15
C-C chemokine receptor type 3 ligand AGN-PC-075BAT family 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor AC1N6ZLA family 1 0
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZK family 3 0
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00395114 CHEMBL255398 Bioactive 1-(3,5-diacetylphenyl)-3-[(2R)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]butan-2-yl]urea
CFAMM00395111 CHEMBL193575 Bioactive 1-(3,5-diacetylphenyl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]urea
CFAMM00395110 CHEMBL383879 Bioactive SureCN6773441
CFAMM00395109 CHEMBL404202 Bioactive 1-(3,5-diacetylphenyl)-3-[(2S)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]butan-2-yl]urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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