CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM941
Family Name Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 receptor EP4 subtype ligand SureCN2986784 family
No. of Seeds 55 No. of Other Members 36
Family Centroid CFAMM00166502 Functional Category Bioactive with Natural Product
Superfamily Microsomal triglyceride transfer protein large subunit Inhibitor SLX-4090 Superfamily
Class Class 1003

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Peroxisome proliferator-activated receptor alpha Ligand Bezafi... 2 17
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
Zucapsacin family 7 177
Cholesteryl ester transfer protein Inhibitor Anacetrapib Family 3 63
C-C chemokine receptor type 2 Ligand CCX915 Family 3 25
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Substance-P receptor Ligand DA-5018 Family 14 73
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 2
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 0
Pol polyprotein inhibitor 180968-31-4 family 8 13
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 4
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 3 2
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Thromboxane A2 receptor ligand 11-[2-(benzylcarbamothioylamino... 1 4
Histamine H1 receptor ligand SureCN5064818 family 4 9
Thromboxane A2 receptor ligand 11-[2-[(3-methylthiophene-2-car... 2 8
Caspase-1 inhibitor 5-(3-carbamoylnaphthalen-2-yl)oxy-3-[[(2S)... 1 11
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-7-[(4-ca... 3 14
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 12 0
Prostaglandin D2 receptor 2 ligand SureCN137334 family 1 0
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Pol polyprotein inhibitor KNI-1279 family 3 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-benzylsul... 2 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
Plasmepsin-1 and Plasmepsin-2 inhibitor N-[(2S,3S)-5-[[(2S)-1-... 1 2
Prostaglandin E2 receptor EP4 subtype ligand 4-[(1S)-1-[[2-(tr... 2 1
Collagenase 3 and 72 kDa type IV collagenase inhibitor N-[(3,4... 1 6
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Free fatty acid receptor 1 ligand 3-[4-[[3-[2,6-dimethyl-4-[3-... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Estrogen receptor ligand 2-(3-hydroxy-6-oxoxanthen-9-yl)-5-[[4... 1 2
Beta-secretase 1 and Cathepsin B inhibitor N-[(2S)-1-[[(2S,3R)... 2 1
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 1 0
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 3 11
Peroxisome proliferator-activated receptor delta and Peroxisom... 13 0
Caspase-1 and Caspase-8 inhibitor N-[(6S)-1-[2-[[(3S)-2-hydrox... 3 1
Estrogen receptor and Estrogen receptor beta ligand SureCN1450... 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Pol polyprotein inhibitor AC1LA3AI family 5 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 0
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 16 2
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 4
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-074LOQ... 3 0
Gonadotropin-releasing hormone receptor ligand N-[[4-[(diamino... 6 4
Integrin beta-3 and Integrin alpha-IIb inhibitor FRADAFIBAN fa... 1 17
Arachidonate 5-lipoxygenase inhibitor methyl 5-[1-(2-butyl-1-b... 2 4
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
Coagulation factor X and Trypsin-1 inhibitor methyl (E)-2-[(3-... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 4 3
Metabotropic glutamate receptor 2 ligand SureCN787402 family 1 8
Cathepsin K inhibitor benzyl N-[(2S)-4-methyl-1-oxo-1-[2-[[(4-... 2 0
Tyrosine-protein kinase Lck inhibitor (4S)-5-[(4-methoxyphenyl... 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Glutamate carboxypeptidase 2 inhibitor 2-(4-hydroxy-3-methoxyp... 1 4
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
Pol polyprotein inhibitor N-[(2S,3R,4R,5R)-1-cyclohexyl-3,4-di... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[(4... 1 0
Putative NP ZINC02127056 Family 4 1
Putative NP ZINC20611663 Family 4 0
Putative NP ZINC02099241 Family 12 0
Putative NP ZINC00519603 Family 8 1
3-(3,4-dimethoxyphenyl)-3-[3-(7-methoxy-4,8-dimethyl-2-oxochro... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00317590 CHEMBL596738 Bioactive AGN-PC-03XGYO
CFAMM00317632 CHEMBL598174 Bioactive AGN-PC-03XGZ5
CFAMM00317596 CHEMBL602688 Bioactive AGN-PC-03XH4O
CFAMM00317610 CHEMBL603881 Bioactive AGN-PC-03XGYF
CFAMM00317625 CHEMBL605974 Bioactive AGN-PC-03XGV1
CFAMM00317652 CHEMBL599835 Bioactive AGN-PC-03XGJP
CFAMM00317602 CHEMBL598410 Bioactive AGN-PC-03XGR8
CFAMM00317582 CHEMBL601029 Bioactive AGN-PC-03XGHP
CFAMM00317595 CHEMBL599419 Bioactive AGN-PC-03XGYQ
CFAMM00317651 CHEMBL598613 Bioactive AGN-PC-03XH5H
CFAMM00317588 CHEMBL606393 Bioactive AGN-PC-03XGZA
CFAMM00317616 CHEMBL599420 Bioactive AGN-PC-03XGPD
CFAMM00317630 CHEMBL597785 Bioactive AGN-PC-03XH4X
CFAMM00317636 CHEMBL1095768 Bioactive SureCN2983915
CFAMM00317629 CHEMBL597147 Bioactive AGN-PC-03XH5O
CFAMM00317642 CHEMBL602337 Bioactive AGN-PC-03XH6L
CFAMM00317580 CHEMBL600831 Bioactive AGN-PC-03XGJS
CFAMM00317622 CHEMBL597974 Bioactive AGN-PC-03XGW3
CFAMM00317586 CHEMBL598795 Bioactive AGN-PC-03XGW7
CFAMM00317649 CHEMBL599213 Bioactive AGN-PC-03XGMK
CFAMM00317614 CHEMBL606181 Bioactive AGN-PC-03XH3A
CFAMM00317641 CHEMBL597367 Bioactive AGN-PC-03XGY9
CFAMM00317579 CHEMBL598995 Bioactive AGN-PC-03XGQL
CFAMM00317592 CHEMBL596745 Bioactive AGN-PC-03XGG1
CFAMM00317634 CHEMBL606195 Bioactive AGN-PC-03XGO2
CFAMM00317621 CHEMBL598409 Bioactive AGN-PC-03XH3L
CFAMM00317585 CHEMBL598796 Bioactive AGN-PC-03XGOC
CFAMM00317648 CHEMBL599811 Bioactive AGN-PC-03XGFX
CFAMM00317612 CHEMBL599836 Bioactive AGN-PC-03XH1V
CFAMM00317627 CHEMBL600209 Bioactive AGN-PC-03XGHZ
CFAMM00317654 CHEMBL604297 Bioactive AGN-PC-03XGVL
CFAMM00317591 CHEMBL598802 Bioactive SureCN2975288
CFAMM00317604 CHEMBL606857 Bioactive AGN-PC-03XGQX
CFAMM00317620 CHEMBL603969 Bioactive AGN-PC-03XGQC
CFAMM00317633 CHEMBL606197 Bioactive AGN-PC-03XGT5
CFAMM00317626 CHEMBL598813 Bioactive AGN-PC-03XGT3
CFAMM00317597 CHEMBL597160 Bioactive AGN-PC-03XGJE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27273 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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