CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9419
Family Name C-C chemokine receptor type 5 and Potassium voltage-gated channel subfamily H member 2 ligand (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[(4-imidazo[1,2-a]pyridin-3-ylpiperidin-1-yl)methyl]pyrrolidin-1-yl]propanoic acid family
No. of Seeds 11 No. of Other Members 0
Family Centroid CFAMM00395229 Functional Category Bioactive
Superfamily C-C chemokine receptor type 5 and Type-1 angiotensin II receptor Binder Superfamily
Class Class 2341

Cousin Family NamesSeedsMembers
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Integrin alpha-4 Inhibitor CDP323 Family 8 17
Thromboxane-A synthase Inhibitor CGS-13080 Family 3 19
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Type-2 angiotensin II receptor Ligand PD-123319 Family 3 39
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Bombesin receptor subtype-3 ligand SureCN3515839 family 1 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor AC1O... 18 10
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-quinolin... 6 8
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 44
C-C chemokine receptor type 5 ligand AC1LA25C family 3 6
C-C chemokine receptor type 5 ligand (2R)-3-cyclobutyl-2-[(3S,... 9 4
Carboxypeptidase B2 and Carboxypeptidase B inhibitor 3-(6-amin... 5 10
Prostaglandin D2 receptor 2 ligand 2-[(8R)-8-[(4-fluorophenyl)... 3 15
Prostaglandin D2 receptor 2 ligand SureCN2215286 family 7 5
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
A disintegrin and metalloproteinase with thrombospondin motifs... 1 3
C-C chemokine receptor type 5 ligand SureCN13543564 family 10 3
C-C chemokine receptor type 5 ligand (2R)-2-[(3S,4S)-3-[[4-(2-... 5 0
C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1
C-C chemokine receptor type 5 ligand (2R)-3-cyclobutyl-2-[(3S,... 2 0
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-(7-aminop... 1 1
Type-1 angiotensin II receptor and Type-1A angiotensin II rece... 3 0
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-00IW9E f... 3 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Prostaglandin D2 receptor 2 and Cholecystokinin receptor type ... 3 4
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-[5-(6-chl... 2 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 6
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Integrin alpha-4 inhibitor (2S)-2-[(2-bromo-3-oxospiro[3.5]non... 9 0
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
A disintegrin and metalloproteinase with thrombospondin motifs... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00395235 CHEMBL193984 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-[[4-(7-ethylimidazo[1,2-a]pyridin-3-yl)piperidin-1-yl]methyl]-4-(3-fluorophenyl)pyrrolidin-1-yl]propanoic acid
CFAMM00395228 CHEMBL435886 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[[4-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]piperidin-1-yl]methyl]pyrrolidin-1-yl]propanoic acid
CFAMM00395234 CHEMBL193988 Bioactive (2R)-2-[(3S,4S)-3-[[4-(6-chloroimidazo[1,2-a]pyridin-3-yl)piperidin-1-yl]methyl]-4-(3-fluorophenyl)pyrrolidin-1-yl]-3-cyclobutylpropanoic acid
CFAMM00395233 CHEMBL436290 Bioactive SureCN7931781
CFAMM00395232 CHEMBL193822 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[[4-(6-phenylimidazo[1,2-a]pyridin-3-yl)piperidin-1-yl]methyl]pyrrolidin-1-yl]propanoic acid
CFAMM00395238 CHEMBL472798 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[(4-imidazo[1,2-a]pyrimidin-3-ylpiperidin-1-yl)methyl]pyrrolidin-1-yl]propanoic acid
CFAMM00395231 CHEMBL2113088 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[(4-imidazo[1,2-a]pyrazin-3-ylpiperidin-1-yl)methyl]pyrrolidin-1-yl]propanoic acid
CFAMM00395237 CHEMBL195753 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[[4-(6-nitroimidazo[1,2-a]pyridin-3-yl)piperidin-1-yl]methyl]pyrrolidin-1-yl]propanoic acid
CFAMM00395230 CHEMBL194497 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-[[4-(6-fluoroimidazo[1,2-a]pyridin-3-yl)piperidin-1-yl]methyl]-4-(3-fluorophenyl)pyrrolidin-1-yl]propanoic acid
CFAMM00395236 CHEMBL371177 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-[[4-(6,8-dichloroimidazo[1,2-a]pyridin-3-yl)piperidin-1-yl]methyl]-4-(3-fluorophenyl)pyrrolidin-1-yl]propanoic acid
CFAMM00395229 CHEMBL2113086 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[(4-imidazo[1,2-a]pyridin-3-ylpiperidin-1-yl)methyl]pyrrolidin-1-yl]propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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