CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9420
Family Name Neuronal acetylcholine receptor subunit alpha-7 and Neuronal acetylcholine receptor subunit beta-2 ligand 5-methyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-2-carboxamide family
No. of Seeds 8 No. of Other Members 5
Family Centroid CFAMM00395243 Functional Category Bioactive with Natural Product
Superfamily Neuronal acetylcholine receptor subunit alpha-7 and Cholinesterase Binder Superfamily
Class Class 2536

Cousin Family NamesSeedsMembers
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Triprolidine Family 19 316
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Amg 423 family 7 47
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Integrin beta-3 Inhibitor L-739758 Family 2 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
D(4) dopamine receptor Ligand ABT-670 Family 4 14
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(2... 2 20
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Sonic hedgehog protein inhibitor 3-chloro-N-[4-(methylamino)cy... 2 3
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1231206 ... 6 7
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-073U... 3 8
Platelet-activating factor receptor ligand YM-461 family 1 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 13
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 4 11
Histamine H3 receptor ligand SureCN1857507 family 1 4
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 4 10
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 8 4
Cyclin-dependent kinase 8 and Cyclin-dependent kinase 5 inhibi... 1 6
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[acetyl(thio... 6 3
C-C chemokine receptor type 5 ligand 6-chloro-2,4-dimethyl-N-[... 1 0
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Histone deacetylase 1 inhibitor N-hydroxy-5-[1-[2-[(1-methylin... 4 1
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
Intercellular adhesion molecule 1 and E-selectin inhibitor Sur... 1 0
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand N-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00395243 CHEMBL2151441 Bioactive 5-methyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-2-carboxamide
CFAMM00395241 CHEMBL193830 Bioactive 5-iodo-N-[(2R,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-2-carboxamide
CFAMM00395245 CHEMBL382101 Bioactive 5-bromo-N-[(2R,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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