CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9422
Family Name Delta-type opioid receptor and Mu-type opioid receptor ligand (4-methylpiperazin-1-yl)-[4-[quinolin-8-yl-[1-(1,3-thiazol-4-ylmethyl)piperidin-4-ylidene]methyl]phenyl]methanone family
No. of Seeds 9 No. of Other Members 16
Family Centroid CFAMM00395264 Functional Category Bioactive with Natural Product
Superfamily Metabotropic glutamate receptor 1 and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 3795

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
DNA primase Inhibitor Bay 57-1293 Family 1 2
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(2... 2 20
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Histamine H3 receptor ligand SureCN2976366 family 4 5
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Coagulation factor X and Prothrombin inhibitor SureCN763988 fa... 31 86
Cathepsin K and Cathepsin S inhibitor N-[1-(cyanomethylcarbamo... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 13
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Prothrombin inhibitor (3R,6S,8aS)-N-[5-(diaminomethylideneamin... 2 3
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 4 10
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 8 4
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Serine/threonine-protein kinase Chk1 inhibitor 2-(1H-indol-5-y... 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 2 0
Cathepsin K and Cathepsin L1 inhibitor (2R)-N-(cyanomethyl)-4-... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 1 0
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
Gamma-aminobutyric acid receptor subunit alpha-2 and Gamma-ami... 6 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 1 2
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 5 0
Coagulation factor X inhibitor SureCN1253902 family 2 0
Metabotropic glutamate receptor 5 ligand 2-(2-pyridin-3-ylethy... 1 2
Metabotropic glutamate receptor 5 ligand N-[(2R)-3-hydroxy-3-m... 1 0
1-(thiophen-2-yl)-8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00395265 CHEMBL1946615 Bioactive morpholin-4-yl-[4-[quinolin-8-yl-[1-(1,3-thiazol-4-ylmethyl)piperidin-4-ylidene]methyl]phenyl]methanone
CFAMM00395264 CHEMBL1946616 Bioactive (4-methylpiperazin-1-yl)-[4-[quinolin-8-yl-[1-(1,3-thiazol-4-ylmethyl)piperidin-4-ylidene]methyl]phenyl]methanone
CFAMM00395286 CHEMBL1946026 Bioactive pyrrolidin-1-yl-[4-[quinolin-8-yl-[1-(1,3-thiazol-4-ylmethyl)piperidin-4-ylidene]methyl]phenyl]methanone
CFAMM00395263 CHEMBL1946617 Bioactive (4-hydroxypiperidin-1-yl)-[4-[quinolin-8-yl-[1-(1,3-thiazol-4-ylmethyl)piperidin-4-ylidene]methyl]phenyl]methanone
CFAMM00395276 CHEMBL1946621 Bioactive N,N-dimethyl-4-[pyridin-2-yl-[1-(1,3-thiazol-4-ylmethyl)piperidin-4-ylidene]methyl]benzamide
CFAMM00395275 CHEMBL1946620 Bioactive N,N-diethyl-4-[pyridin-2-yl-[1-(1,3-thiazol-4-ylmethyl)piperidin-4-ylidene]methyl]benzamide
CFAMM00395282 CHEMBL1946028 Bioactive azetidin-1-yl-[4-[quinolin-8-yl-[1-(1,3-thiazol-4-ylmethyl)piperidin-4-ylidene]methyl]phenyl]methanone
CFAMM00395260 CHEMBL1946618 Bioactive N-(2-hydroxyethyl)-N-methyl-4-[quinolin-8-yl-[1-(1,3-thiazol-4-ylmethyl)piperidin-4-ylidene]methyl]benzamide
CFAMM00395273 CHEMBL1938410 Bioactive N-ethyl-N-methyl-4-[(R)-pyridin-3-yl-[4-(1,3-thiazol-4-ylmethyl)piperazin-1-yl]methyl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27430 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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