CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9439
Family Name Lysine-specific histone demethylase 1A and Amine oxidase [flavin-containing] A inhibitor 2-[[2-[4-[5-fluoro-2-(trifluoromethyl)phenyl]phenyl]cyclopropyl]amino]-1-(4-methylpiperazin-1-yl)ethanone family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00395474 Functional Category Bioactive
Superfamily Dipeptidyl peptidase 4 Inhibitor Denagliptin Superfamily
Class Class 1224

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Substance-P receptor Ligand Orvepitant Family 11 46
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 1 1
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 0
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00395474 CHEMBL1938898 Bioactive 2-[[2-[4-[5-fluoro-2-(trifluoromethyl)phenyl]phenyl]cyclopropyl]amino]-1-(4-methylpiperazin-1-yl)ethanone
CFAMM00395475 CHEMBL221695 Bioactive N-[(1R)-1-[2-fluoro-4-[3-fluoro-2-(trifluoromethyl)phenyl]phenyl]ethyl]-1-[(2,2,2-trifluoroacetyl)amino]cyclopropane-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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