CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Renin and Pepsin A inhibitor tert-butyl N-[(2S)-1-[[2-[[(4S,5S,7S)-7-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]carbamoyl]-5-hydroxy-2,8-dimethylnonan-4-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00317720 Functional Category Bioactive
Superfamily Renin and C-C chemokine receptor type 5 Binder Superfamily
Class Class 1170

Cousin Family NamesSeedsMembers
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Renin Inhibitor Remikiren Family 100 126
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Pol polyprotein inhibitor (2S)-N-[(2S,4S,5S)-4-hydroxy-5-[[(2S... 1 3
Renin and Cathepsin D inhibitor tert-butyl N-[(2R)-1-[[3-[[(2R... 19 4
Pol polyprotein inhibitor Hydroxyethylene deriv. 12 family 13 10
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-meth... 3 4
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5S)-5-(... 2 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0


External ID

Functional Category

Molecule Name

CFAMM00317722 CHEMBL324213 Bioactive tert-butyl N-[(2S)-4-[2-[[(4S,5S,7S)-7-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]carbamoyl]-5-hydroxy-2,8-dimethylnonan-4-yl]amino]-2-oxoethyl]sulfanyl-3-oxo-1-phenylbutan-2-yl]carbamate
CFAMM00317721 CHEMBL112778 Bioactive tert-butyl N-[(2S)-6-[[(4S,5S,7S)-7-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]carbamoyl]-5-hydroxy-2,8-dimethylnonan-4-yl]amino]-3,6-dioxo-1-phenylhexan-2-yl]carbamate
CFAMM00317720 CHEMBL109429 Bioactive tert-butyl N-[(2S)-1-[[2-[[(4S,5S,7S)-7-[[(2S,3S)-1-[(4-amino-2-methylpyrimidin-5-yl)methylamino]-3-methyl-1-oxopentan-2-yl]carbamoyl]-5-hydroxy-2,8-dimethylnonan-4-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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