CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9441
Family Name Neuronal acetylcholine receptor subunit alpha-4 and Neuronal acetylcholine receptor subunit beta-2 ligand SureCN1135274 family
No. of Seeds 5 No. of Other Members 4
Family Centroid CFAMM00395480 Functional Category Bioactive
Superfamily Sodium- and Prothrombin Binder Superfamily
Class Class 930

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Reverse transcriptase Inhibitor Nevirapine Family 23 640
26S proteasome Inhibitor Bortezomib Family 7 65
Histamine H1 receptor Ligand Alcaftadine Family 1 4
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
Translocator protein Inhibitor Emapunil Family 7 89
Aurora kinase B and Aurora kinase A Inhibitor PF-03814735 Family 2 12
Dipeptidyl peptidase 4 Inhibitor SSR-162369 Family 8 27
GP-531 family 1 33
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
Toll-like receptor 7 Ligand GS-9620 Family 2 4
XL-888 family 16 85
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Histamine H3 receptor Ligand SCH79687 Family 11 29
Herpes simplex virus type 1 thymidine kinase Inhibitor 9-(4-hy... 2 13
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
Cannabinoid receptor 1 Ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 18 41
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Thromboxane-A synthase inhibitor AGN-PC-00N7V2 family 3 6
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 2 0
Dipeptidyl peptidase 4 inhibitor Xanthine Analogue 4 family 1 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKE family 3 5
Dipeptidyl peptidase 4 inhibitor Xanthine mimetic compound 8 f... 2 2
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Vascular endothelial growth factor receptor 2 ligand AC1LLCDM ... 1 2
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Prelamin-A/C inhibitor CHEMBL1503535 family 1 0
Cellular tumor antigen p53 and Thyrotropin receptor ligand CHE... 1 5
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 13
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Prothrombin inhibitor AGN-PC-0748PG family 1 0
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 1 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Adenosine receptor A3 ligand 3-(cyclopropylmethyl)-8-methoxy-1... 1 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(tria... 1 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Dipeptidyl peptidase 4 inhibitor 2-(3-aminopiperidin-1-yl)-3-b... 4 1
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 8
Adenosine receptor A1 ligand 3-(4-Aminophenethyl)-8-(3-noradam... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Tripeptidyl-peptidase 2 inhibitor (2S)-2-amino-1-[(2S)-5-chlor... 1 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cathepsin S and Cathepsin K inhibitor 2-cyano-N-[(2R)-1-phenyl... 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 5 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0
Sodium- and chloride-dependent glycine transporter 1 and Potas... 3 0
Histone deacetylase 1 inhibitor SureCN4538615 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00395480 CHEMBL1939290 Bioactive SureCN1135274
CFAMM00395485 CHEMBL1939283 Bioactive SureCN1135580
CFAMM00395484 CHEMBL1939286 Bioactive SureCN1135346
CFAMM00395483 CHEMBL1939296 Bioactive SureCN1135255
CFAMM00395482 CHEMBL1939295 Bioactive SureCN1135319

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26853 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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