CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9442
Family Name Sodium- and chloride-dependent glycine transporter 1 and Sodium- and chloride-dependent glycine transporter 2 inhibitor AGN-PC-07C6ST family
No. of Seeds 4 No. of Other Members 8
Family Centroid CFAMM00395494 Functional Category Bioactive
Superfamily Farnesyltransferase beta subunit, putative and Protein farnesyltransferase subunit beta Inhibitor L-778123 Superfamily
Class Class 1486

Cousin Family NamesSeedsMembers
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Adenosine deaminase Inhibitor FR221647 Family 1 4
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
Cannabinoid receptor 1 Ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 18 41
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Dipeptidyl peptidase 4 inhibitor Xanthine Analogue 4 family 1 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKE family 3 5
Dipeptidyl peptidase 4 inhibitor Xanthine mimetic compound 8 f... 2 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 4 inhibitor Su... 5 13
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Bile acid receptor and Potassium voltage-gated channel subfami... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 2 0
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
C-X-C chemokine receptor type 3 ligand 3-amino-6-chloro-5-[(3S... 11 1
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 5 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 1 0
Mitogen-activated protein kinase 8 inhibitor 4-[(6-chloro-1-ox... 1 1
Tripeptidyl-peptidase 2 inhibitor (2S)-2-amino-1-[(2S)-5-chlor... 1 0
Corticotropin-releasing factor receptor 1 ligand SureCN6323029... 2 13
Histamine H3 receptor ligand SureCN1382602 family 6 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0
Sodium- and chloride-dependent glycine transporter 1 and Potas... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00395494 CHEMBL563761 Bioactive AGN-PC-07C6ST
CFAMM00395487 CHEMBL1939294 Bioactive SureCN1135447
CFAMM00395497 CHEMBL596895 Bioactive AGN-PC-07R9YP
CFAMM00395489 CHEMBL551424 Bioactive N-[(3-chlorophenyl)methyl]-N-[[(1R,5S)-3-ethyl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-1-methylimidazole-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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