CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9450
Family Name Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,5-dimethoxyphenyl)-3,7-dimethyl-5-pentan-3-ylpyrrolo[1,2-b]pyridazine family
No. of Seeds 4 No. of Other Members 9
Family Centroid CFAMM00395537 Functional Category Bioactive
Superfamily Cellular tumor antigen p53 and Thioredoxin glutathione reductase Binder Superfamily
Class Class 1076

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
PF-02545920 family 16 140
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Interleukin-4 Inhibitor SIL-4R Family 2 16
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUW... 2 9
Sigma non-opioid intracellular receptor 1 ligand 1'-butyl-6-me... 23 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Coagulation factor X and Prothrombin inhibitor AGN-PC-0759SH f... 5 4
Voltage-dependent calcium channel subunit alpha-2/delta-1 and ... 9 15
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 40
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Adenosine receptor A1 ligand BAS 00727702 family 1 4
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Thyroid hormone receptor beta and TGF-beta receptor type-1 lig... 1 1
Cytochrome P450 2D6 inhibitor AGN-PC-0509UI family 1 2
Beta-lactamase and Muscleblind-like protein 1 inhibitor 2,3-Bi... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00395545 CHEMBL1939569 Bioactive 2-(4-methoxy-2-methylphenyl)-3,7-dimethyl-5-pentan-3-ylpyrrolo[1,2-b]pyridazine
CFAMM00395537 CHEMBL1939576 Bioactive 2-(2-ethyl-4,5-dimethoxyphenyl)-3,7-dimethyl-5-pentan-3-ylpyrrolo[1,2-b]pyridazine
CFAMM00395536 CHEMBL1939575 Bioactive 3,7-dimethyl-2-(6-methyl-1,3-benzodioxol-5-yl)-5-pentan-3-ylpyrrolo[1,2-b]pyridazine
CFAMM00395535 CHEMBL1939574 Bioactive 2-(4-ethoxy-2-ethylphenyl)-3,7-dimethyl-5-pentan-3-ylpyrrolo[1,2-b]pyridazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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