CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM946
Family Name Serine/threonine-protein kinase PLK1 and Serine/threonine-protein kinase PLK3 inhibitor SureCN3503601 family
No. of Seeds 14 No. of Other Members 42
Family Centroid CFAMM00317770 Functional Category Bioactive
Superfamily Renin and Insulin-like growth factor 1 receptor Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
DCC-2036 family 2 5
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
PHA848125 family 13 138
MK-6096 family 3 69
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 4 4
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 1-methyl-8-(... 1 1
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 4 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M4U... 4 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 5 19
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-3-... 1 1
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Hepatocyte growth factor receptor ligand 5-[[6-(3-hydroxypheny... 2 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YLX fa... 3 1
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Coagulation factor X and Prothrombin inhibitor 1-(4-methoxyphe... 8 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Adenosine receptor A1 ligand ethyl 1-(2-chloro-2-phenylethyl)-... 5 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(4-methoxyphenyl)... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Hepatocyte growth factor receptor ligand AGN-PC-00AG7Q family 1 10
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Coagulation factor X inhibitor 2-(4-methoxyphenyl)-N-[5-(2-sul... 1 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Vascular endothelial growth factor receptor 2 and Vascular end... 2 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Coagulation factor X inhibitor SureCN5641901 family 5 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 1
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07B2Q... 6 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07RBL... 5 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 8 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00317783 CHEMBL1738758 Bioactive NMS-P937
CFAMM00317770 CHEMBL1271590 Bioactive SureCN3503601
CFAMM00317749 CHEMBL1793891 Bioactive AGN-PC-0BFOD1
CFAMM00317754 CHEMBL1793896 Bioactive AGN-PC-0BFJ6I
CFAMM00317752 CHEMBL1793895 Bioactive AGN-PC-0BFV3O
CFAMM00317745 CHEMBL1774327 Bioactive AGN-PC-0A9TCW
CFAMM00317772 CHEMBL1272140 Bioactive SureCN3503253
CFAMM00317751 CHEMBL1793892 Bioactive AGN-PC-0BFRSF
CFAMM00317764 CHEMBL1094408 Bioactive AGN-PC-04VDPI
CFAMM00317778 CHEMBL1271644 Bioactive SureCN3503624
CFAMM00317731 CHEMBL605153 Bioactive AGN-PC-07B0U7
CFAMM00317750 CHEMBL1793893 Bioactive AGN-PC-0BFMNU

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27038 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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