CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9477
Family Name B1 bradykinin receptor ligand N-[(4S)-1-ethyl-3,3-dimethylpiperidin-4-yl]-2-[(3R)-4-(4-methylphenyl)sulfonyl-2-oxo-1,3-dihydropyrazin-3-yl]acetamide family
No. of Seeds 10 No. of Other Members 4
Family Centroid CFAMM00395791 Functional Category Bioactive with Natural Product
Superfamily B1 bradykinin receptor Binder Superfamily 4
Class Class 4312

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A and Sigma non-opioid intracell... 7 28
Thymidylate synthase Inhibitor N-[tosyl-d-prolinyl]amino-ethan... 1 10
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 6
Neutrophil elastase inhibitor 2-[3-(benzylsulfamoylamino)-2-ox... 5 27
Prothrombin and Trypsin-1 inhibitor AGN-PC-073KRV family 3 4
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
B1 bradykinin receptor ligand 2-[1-(4-chlorophenyl)sulfonyl-3-... 5 9
B1 bradykinin receptor ligand SureCN13936521 family 19 4
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-[2-[... 10 5
Bifunctional epoxide hydrolase 2 inhibitor N-cycloheptyl-1-(2,... 7 8
B1 bradykinin receptor ligand N-[(1R)-6-[(dimethylamino)methyl... 7 6
B1 bradykinin receptor ligand N-[(4R)-1,1-dioxo-3,4-dihydro-2H... 1 0
Proteasome subunit beta type-5 inhibitor (2S)-N'-(2,2-dimethyl... 2 9
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-oxo-5-... 2 15
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Calpain-2 catalytic subunit and Calpain small subunit 1 inhibi... 1 0
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 8 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00395790 CHEMBL1939931 Bioactive 2-[(3R)-4-(4-methylphenyl)sulfonyl-2-oxo-1,3-dihydropyrazin-3-yl]-N-[(4S)-1,3,3-trimethylpiperidin-4-yl]acetamide
CFAMM00395796 CHEMBL1939929 Bioactive N-[(4S)-3,3-dimethylpiperidin-4-yl]-2-[(3R)-4-(4-methylphenyl)sulfonyl-2-oxo-1,3-dihydropyrazin-3-yl]acetamide
CFAMM00395789 CHEMBL1939937 Bioactive N-[(4S)-1-cyclopropyl-3,3-dimethylpiperidin-4-yl]-2-[(3R)-4-(4-methylphenyl)sulfonyl-2-oxo-1,3-dihydropyrazin-3-yl]acetamide
CFAMM00395788 CHEMBL1939936 Bioactive N-[(4S)-1-benzyl-3,3-dimethylpiperidin-4-yl]-2-[(3R)-4-(4-methylphenyl)sulfonyl-2-oxo-1,3-dihydropyrazin-3-yl]acetamide
CFAMM00395794 CHEMBL1939939 Bioactive N-[(4S)-1-cyclopentyl-3,3-dimethylpiperidin-4-yl]-2-[(3R)-4-(4-methylphenyl)sulfonyl-2-oxo-1,3-dihydropyrazin-3-yl]acetamide
CFAMM00395787 CHEMBL1939935 Bioactive N-[(4S)-1-(2,2-dimethylpropyl)-3,3-dimethylpiperidin-4-yl]-2-[(3R)-4-(4-methylphenyl)sulfonyl-2-oxo-1,3-dihydropyrazin-3-yl]acetamide
CFAMM00395793 CHEMBL1939938 Bioactive N-[(4S)-1-cyclobutyl-3,3-dimethylpiperidin-4-yl]-2-[(3R)-4-(4-methylphenyl)sulfonyl-2-oxo-1,3-dihydropyrazin-3-yl]acetamide
CFAMM00395786 CHEMBL1939934 Bioactive N-[(4S)-3,3-dimethyl-1-(2-methylpropyl)piperidin-4-yl]-2-[(3R)-4-(4-methylphenyl)sulfonyl-2-oxo-1,3-dihydropyrazin-3-yl]acetamide
CFAMM00395792 CHEMBL1939933 Bioactive N-[(4S)-3,3-dimethyl-1-propylpiperidin-4-yl]-2-[(3R)-4-(4-methylphenyl)sulfonyl-2-oxo-1,3-dihydropyrazin-3-yl]acetamide
CFAMM00395791 CHEMBL1939932 Bioactive N-[(4S)-1-ethyl-3,3-dimethylpiperidin-4-yl]-2-[(3R)-4-(4-methylphenyl)sulfonyl-2-oxo-1,3-dihydropyrazin-3-yl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543