CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9482
Family Name Platelet-derived growth factor receptor beta and Receptor-type tyrosine-protein kinase FLT3 ligand 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-N-(1-ethylpyrazol-4-yl)acetamide family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00144536 Functional Category Bioactive
Superfamily Hepatocyte growth factor receptor and Vascular endothelial growth factor receptor 2 Binder Superfamily
Class Class 938

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Tivozanib family 4 6
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 1 2
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Platelet-derived growth factor receptor beta and Macrophage co... 8 0
Platelet-derived growth factor receptor beta ligand N-(4,5-dim... 5 1
Platelet-derived growth factor receptor beta and Macrophage co... 7 0
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Hepatocyte growth factor receptor and Vascular endothelial gro... 15 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Aurora kinase A inhibitor SureCN4289024 family 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00395834 CHEMBL1940268 Bioactive 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-N-(5-ethyl-1H-pyrazol-3-yl)acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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