CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM949
Family Name Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand AGN-PC-04XMIX family
No. of Seeds 6 No. of Other Members 6
Family Centroid CFAMM00317820 Functional Category Bioactive
Superfamily Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Binder Superfamily
Class Class 605

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Histamine H1 receptor Ligand Doxepin Family 8 89
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
DNA topoisomerase 2-beta Inhibitor Etoposide Family 3 29
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
Chromomycin A3 family 7 14
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
DNA topoisomerase 2-beta Inhibitor TOP-53 Family 2 12
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Endothelin-1 receptor Ligand PD156707 Family 41 211
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Endothelin B receptor and Endothelin-1 receptor Ligand PD-1631... 9 13
Protein kinase C alpha type and Protein kinase C beta type Inh... 7 1
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Protein kinase C alpha type and Protein kinase C beta type Inh... 2 1
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
NF-kappa-B Inhibitor Rocaglamide Family 8 8
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
72 kDa type IV collagenase Inhibitor Lithospermic Acid Family 1 0
Leukotriene B4 receptor 1 ligand AGN-PC-04XMB7 family 3 18
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 4
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-[(1S,3S,5... 2 0
Free fatty acid receptor 1 ligand 3-[4-[[3-[2,6-dimethyl-4-[3-... 1 0
Free fatty acid receptor 1 ligand 3-[4-[[3-[4-(1,1-dioxothian-... 3 0
Arachidonate 5-lipoxygenase inhibitor methyl (2S)-2-[3-fluoro-... 2 0
Endothelin-1 receptor ligand SureCN8117947 family 1 3
Eukaryotic initiation factor 4A-I inhibitor methyl (1R,2R,3S,3... 12 1
Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
Androgen receptor and Estrogen receptor ligand estradiol benzo... 1 29
Endothelin-1 receptor and Endothelin B receptor ligand SureCN7... 2 2
Endothelin-1 receptor ligand SureCN7952886 family 1 0
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R)... 1 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 7
Free fatty acid receptor 1 ligand 2-[(8S)-3-(3-bromophenyl)-2,... 2 3
Free fatty acid receptor 1 ligand 2-[(3R,8S)-3-(3-chlorophenyl... 2 2
Free fatty acid receptor 1 ligand 2-[(8S)-3-[5-[2-chloro-4-(3-... 3 3
Arachidonate 5-lipoxygenase inhibitor 5-(1,3-benzodioxol-5-yl)... 2 2
Vitamin K epoxide reductase complex subunit 1 inhibitor AGN-PC... 1 0
Putative NP ZINC02398203 Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00317812 CHEMBL1099324 Bioactive SureCN1689768
CFAMM00317810 CHEMBL1099337 Bioactive AGN-PC-04XMF3
CFAMM00317809 CHEMBL1099338 Bioactive AGN-PC-07ZF0D
CFAMM00317820 CHEMBL1094348 Bioactive AGN-PC-04XMIX
CFAMM00317819 CHEMBL1094349 Bioactive AGN-PC-04XMIU
CFAMM00317813 CHEMBL1099328 Bioactive AGN-PC-07ZF0A

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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