CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9493
Family Name MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophenyl)-N-[(2-phenylphenyl)methyl]-N-(4-piperazin-1-ylphenyl)furan-2-carboxamide family
No. of Seeds 3 No. of Other Members 8
Family Centroid CFAMM00395935 Functional Category Bioactive
Superfamily Macrophage colony-stimulating factor 1 receptor and Menin Binder Superfamily
Class Class 2780

Cousin Family NamesSeedsMembers
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
Mucosal addressin cell adhesion molecule 1 Inhibitor PF-005476... 64 96
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Sodium channel protein type 10 subunit alpha Ligand A-803467 F... 2 81
Histamine H3 receptor Ligand A-317920 Family 9 240
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Granulocyte colony-stimulating factor receptor Ligand N-(2-mor... 1 24
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 17
Substance-K receptor ligand 5-chloro-N-[1-[[(2S)-5-[4-(oxan-4-... 2 4
Beta-secretase 1 inhibitor SureCN3599637 family 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 4
Sodium channel protein type 10 subunit alpha ligand AGN-PC-09M... 1 7
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Prostaglandin E2 receptor EP4 subtype ligand SureCN5653729 family 3 2
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Collagenase 3 and Matrilysin inhibitor N-({4'-[(1-BENZOFURAN-2... 24 45
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Translocator protein inhibitor N-[(2,5-dimethoxyphenyl)methyl]... 1 0
Histamine H3 receptor ligand SureCN5221194 family 1 8
Histamine H3 receptor ligand SureCN5218144 family 4 6
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
MAP kinase-activated protein kinase 2 inhibitor 4-[5-[[2-(2-me... 3 4
MAP kinase-activated protein kinase 2 inhibitor 4-[4-oxo-8-pip... 4 0
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 4 13
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 6 1
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 5 6
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 1 0
5-hydroxytryptamine receptor 1A ligand SureCN10513645 family 9 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Oxytocin receptor and Vasopressin V1a receptor ligand N-[[5-[4... 1 0
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 3 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Sphingosine 1-phosphate receptor 4 ligand AGN-PC-079GSR family 11 7
Nuclear receptor ROR-gamma and Niemann-Pick C1 protein ligand ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00395930 CHEMBL1940645 Bioactive 5-(4-cyanophenyl)-N-[[2-(4-cyanophenyl)phenyl]methyl]-N-(4-piperazin-1-ylphenyl)furan-2-carboxamide
CFAMM00395935 CHEMBL1940518 Bioactive 5-(4-cyanophenyl)-N-[(2-phenylphenyl)methyl]-N-(4-piperazin-1-ylphenyl)furan-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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