CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9521
Family Name Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-(3-METHYLPHENYL)-1,3-THIAZOL-5-YL]-2-PYRIDYL]-3-PHENYLPROPIONAMIDE family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00396150 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 14 and Vascular endothelial growth factor receptor 2 Binder Superfamily
Class Class 1151

Cousin Family NamesSeedsMembers
Abelson tyrosine-protein kinase 2 inhibitor thiazole derivativ... 19 50
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase A Inhibitor ABT-348 Family 20 49
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing... 3 16
DNA primase Inhibitor Bay 57-1293 Family 1 2
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Metabotropic glutamate receptor 5 Ligand N-[4-(3-pyridylethyny... 2 10
C-C chemokine receptor type 4 Ligand N-(naphthalen-1-yl)-4-neo... 5 78
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Arachidonate 5-lipoxygenase Inhibitor N-(thiazol-2-yl)benzamid... 3 53
Arachidonate 5-lipoxygenase Inhibitor 2-phenyl-n-(thiazol-2-yl... 3 27
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Mitogen-activated protein kinase 11 and Mitogen-activated prot... 10 31
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Prostaglandin D2 receptor 2 ligand AGN-PC-0143RG family 6 13
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Prostaglandin D2 receptor 2 ligand SureCN5315422 family 2 2
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 12 85
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 2 5
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 2 0
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 2
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Cyclin-dependent kinase 5 and G1/S-specific cyclin-E1 inhibito... 1 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Prostaglandin D2 receptor 2 ligand SureCN5318360 family 4 1
Integrin beta-3 and Integrin alpha-V inhibitor SureCN5848255 f... 3 0
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
Cathepsin K and Cathepsin L1 inhibitor (2R)-N-(cyanomethyl)-4-... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Metabotropic glutamate receptor 5 ligand 5-methyl-N-(4-methyl-... 1 2
Cholinesterase and Acetylcholinesterase inhibitor 3-[ethyl-[3-... 6 9
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 2 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Serine/threonine-protein kinase Chk1 inhibitor 2-(1,3-dihydroi... 2 5
Serine/threonine-protein kinase Chk1 inhibitor 2-indazol-1-yl-... 4 5
Orexin receptor type 2 and Orexin receptor type 1 ligand 6-ami... 3 1
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Glucocorticoid receptor ligand 3-[1-(3-chloro-4-fluorophenyl)i... 2 0
Glucocorticoid receptor ligand 3-(1H-indol-5-yl)-2,2-dimethyl-... 2 7
Glucocorticoid receptor ligand (3R)-3-[1-(4-fluorophenyl)indaz... 4 2
MAP kinase-activated protein kinase 2 inhibitor 2-[(4,4-dimeth... 11 11
Thrombopoietin receptor ligand N-[4-[2-fluoro-3-(trifluorometh... 2 14
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Neuropeptide Y receptor type 5 ligand 2-(dimethylamino)-1-[4-[... 10 5
Neuropeptide Y receptor type 5 ligand 1-[4-[[(9-fluoro-5,6-dih... 11 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MSE family 18 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MPV family 4 0
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
Vascular endothelial growth factor receptor 2 ligand Thienopyr... 2 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HL8Q family 4 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HLHQ family 2 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 5 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 1
Proto-oncogene tyrosine-protein kinase LCK and Tyrosine-protei... 3 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 3
Probable G-protein coupled receptor 142 ligand (2S)-3-phenyl-N... 2 2
Cyclin-dependent kinase 5 and G1/S-specific cyclin-E1 inhibito... 2 1
Methionine aminopeptidase 1 inhibitor N-[5-[2-oxo-2-[4-(2-pyri... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00396154 CHEMBL197581 Bioactive N-[4-[2-ETHYL-4-(3-METHYLPHENYL)-1,3-THIAZOL-5-YL]-2-PYRIDYL]PHENYLACETAMIDE
CFAMM00396151 CHEMBL198383 Bioactive N-[4-[2-ETHYL-4-(3-METHYLPHENYL)-1,3-THIAZOL-5-YL]-2-PYRIDYL]CYCLOHEXANECARBOXAMIDE
CFAMM00396150 CHEMBL194201 Bioactive N-[4-[2-ETHYL-4-(3-METHYLPHENYL)-1,3-THIAZOL-5-YL]-2-PYRIDYL]-3-PHENYLPROPIONAMIDE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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