CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9534
Family Name Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-3-fluoro-5-[3-(2-fluoro-6-methylphenyl)-5-methyl-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-4-methylbenzamide family
No. of Seeds 13 No. of Other Members 1
Family Centroid CFAMM00396223 Functional Category Bioactive
Superfamily Hepatocyte growth factor receptor and Type-1 angiotensin II receptor Binder Superfamily
Class Class 2684

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Smoothened homolog inhibitor SureCN1091571 family 2 2
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 6 18
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 3
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Hepatocyte growth factor receptor ligand 5-[(6-phenyl-[1,2,4]t... 6 2
Hepatocyte growth factor receptor ligand 5-[(6-thiophen-3-yl-[... 1 1
Hepatocyte growth factor receptor ligand 5-[[6-(3-hydroxypheny... 2 0
Diacylglycerol O-acyltransferase 1 inhibitor 2,2-dimethyl-3-[[... 1 9
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00396228 CHEMBL1945721 Bioactive 3-[3-(2-chloro-6-fluorophenyl)-5-methyl-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-N-cyclopropyl-5-fluoro-4-methylbenzamide
CFAMM00396221 CHEMBL1945715 Bioactive N-cyclopropyl-3-[3-(2,6-difluorophenyl)-5-methyl-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-4-methylbenzamide
CFAMM00396227 CHEMBL1945720 Bioactive N-cyclopropyl-3-[3-(2,6-difluorophenyl)-5-methyl-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-5-fluoro-4-methylbenzamide
CFAMM00396220 CHEMBL1945716 Bioactive 3-[3-(2-chloro-6-fluorophenyl)-5-methyl-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-N-cyclopropyl-4-methylbenzamide
CFAMM00396226 CHEMBL1945723 Bioactive 3-[3-(2-chloro-6-fluorophenyl)-5-ethyl-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-N-cyclopropyl-4-methylbenzamide
CFAMM00396219 CHEMBL1945717 Bioactive N-cyclopropyl-3-[3-(2-fluoro-6-methylphenyl)-5-methyl-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-4-methylbenzamide
CFAMM00396225 CHEMBL1945722 Bioactive N-cyclopropyl-3-[3-(2,6-difluorophenyl)-5-ethyl-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-4-methylbenzamide
CFAMM00396218 CHEMBL1945718 Bioactive 3-[3-(2-chloro-5-fluorophenyl)-5-methyl-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-N-cyclopropyl-4-methylbenzamide
CFAMM00396231 CHEMBL1945725 Bioactive N-cyclopropyl-3-[3-(2,6-difluorophenyl)-5-ethyl-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-5-fluoro-4-methylbenzamide
CFAMM00396224 CHEMBL1945839 Bioactive N-cyclopropyl-3-[5-ethyl-3-(2-fluoro-6-methylphenyl)-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-5-fluoro-4-methylbenzamide
CFAMM00396230 CHEMBL1945724 Bioactive N-cyclopropyl-3-[5-ethyl-3-(2-fluoro-6-methylphenyl)-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-4-methylbenzamide
CFAMM00396223 CHEMBL1944649 Bioactive N-cyclopropyl-3-fluoro-5-[3-(2-fluoro-6-methylphenyl)-5-methyl-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-4-methylbenzamide
CFAMM00396229 CHEMBL1945726 Bioactive 3-[3-(2-chloro-6-fluorophenyl)-5-ethyl-6-oxo-[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-N-cyclopropyl-5-fluoro-4-methylbenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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