CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9540
Family Name Type-1 angiotensin II receptor and Type-2 angiotensin II receptor ligand 2-[4-[[6-[(2-methoxyphenyl)methylcarbamoyl]-4-methyl-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid family
No. of Seeds 4 No. of Other Members 29
Family Centroid CFAMM00396367 Functional Category Bioactive
Superfamily Type-1 angiotensin II receptor and Coagulation factor X Binder Superfamily
Class Class 1256

Cousin Family NamesSeedsMembers
Type-1 angiotensin II receptor Ligand Candesartan Family 3 75
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Type-1 angiotensin II receptor Ligand Eprosartan Family 36 176
BIBT986 family 7 96
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing... 2 1
Eluxadoline family 4 85
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-57893 Family 3 8
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-7-[1H-b... 3 6
Thromboxane A2 receptor ligand AC1NSKJR family 13 42
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 10 54
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 9
B2 bradykinin receptor ligand SureCN7977402 family 5 6
Thyroid hormone receptor beta ligand CHEMBL1325165 family 1 6
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
B2 bradykinin receptor ligand SureCN8516699 family 3 2
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Microsomal triglyceride transfer protein large subunit inhibit... 7 4
NS5B protein inhibitor (2E)-1-cyclohexyl-2-(2-fluoro-4-oxocycl... 2 10
Elongation factor 1-alpha 1 and Elongation factor 1-alpha 2 in... 2 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Type-1 angiotensin II receptor ligand 7-methyl-N-(2-phenylethy... 2 10
Type-1 angiotensin II receptor ligand N-[2-(3-methoxyphenyl)et... 2 0
Coagulation factor X inhibitor AGN-PC-07C10A family 3 2
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 7 15
Melanocortin receptor 4 ligand AGN-PC-076AMT family 2 9
B2 bradykinin receptor ligand SureCN7976932 family 2 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 6
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 1 1
NS5B protein and Genome polyprotein inhibitor AC1LAG00 family 1 19
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Gastrin/cholecystokinin type B receptor ligand AGN-PC-077L8M f... 24 10
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Type-1A angiotensin II receptor ligand 2-[4-[[2-butyl-5-(tert-... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07C5JC family 1 3
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
NS5B protein inhibitor AGN-PC-00HCFC family 1 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00396367 CHEMBL1947129 Bioactive 2-[4-[[6-[(2-methoxyphenyl)methylcarbamoyl]-4-methyl-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid
CFAMM00396378 CHEMBL1945010 Bioactive 2-[4-[[6-[2-(2,5-dimethoxyphenyl)ethylcarbamoyl]-4-methyl-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid
CFAMM00396364 CHEMBL1947131 Bioactive 2-[4-[[6-[(4-methoxyphenyl)methylcarbamoyl]-4-methyl-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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