CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9548
Family Name Translocator protein inhibitor N,N-diethyl-11-(2-fluoroethyl)-6H-thiochromeno[4,3-b]indole-6-carboxamide family
No. of Seeds 14 No. of Other Members 9
Family Centroid CFAMM00396441 Functional Category Bioactive
Superfamily Muscleblind-like protein 1 and Survival motor neuron protein Binder Superfamily 6
Class Class 1827

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Setipiprant family 5 118
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 20 37
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 14 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 2 9
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Substance-P receptor ligand SureCN7796965 family 9 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Prostaglandin D2 receptor 2 ligand 2-[3-[(3-chlorophenyl)-meth... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-(1-... 3 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
C-X-C chemokine receptor type 2 and Cytochrome P450 2C9 ligand... 1 7
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AC1M4... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Translocator protein inhibitor 2-(7-Chloro-5-methyl-4-oxo-3-ph... 1 0
Phospholipase A2, membrane associated inhibitor 4-[3-(2-amino-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00396439 CHEMBL2377359 Bioactive AGN-PC-014RAD
CFAMM00396461 CHEMBL2377332 Bioactive 3-acetamido-N,N-diethyl-11-(2-fluoroethyl)-6H-thiochromeno[4,3-b]indole-6-carboxamide
CFAMM00396460 CHEMBL2377330 Bioactive N,N-diethyl-11-(2-fluoroethyl)-5,5-dioxo-6H-thiochromeno[4,3-b]indole-6-carboxamide
CFAMM00396451 CHEMBL2377360 Bioactive N,N-diethyl-11-(3-fluoropropyl)-6H-thiochromeno[4,3-b]indole-6-carboxamide
CFAMM00396459 CHEMBL2377331 Bioactive 3-[acetyl(2-fluoroethyl)amino]-N,N-diethyl-11-(2-fluoroethyl)-6H-thiochromeno[4,3-b]indole-6-carboxamide
CFAMM00396450 CHEMBL2377343 Bioactive 8-cyano-N,N-diethyl-11-(2-fluoroethyl)-6H-thiochromeno[4,3-b]indole-6-carboxamide
CFAMM00396436 CHEMBL2377352 Bioactive 8-chloro-N,N-diethyl-11-(2-fluoroethyl)-6H-thiochromeno[4,3-b]indole-6-carboxamide
CFAMM00396442 CHEMBL2377336 Bioactive AGN-PC-07BUUI
CFAMM00396449 CHEMBL2377347 Bioactive N,N-diethyl-8-fluoro-11-(2-fluoroethyl)-6H-thiochromeno[4,3-b]indole-6-carboxamide
CFAMM00396457 CHEMBL2377335 Bioactive AGN-PC-07BUUJ
CFAMM00396441 CHEMBL1945412 Bioactive N,N-diethyl-11-(2-fluoroethyl)-6H-thiochromeno[4,3-b]indole-6-carboxamide
CFAMM00396448 CHEMBL2377346 Bioactive 8-bromo-N,N-diethyl-11-(2-fluoroethyl)-6H-thiochromeno[4,3-b]indole-6-carboxamide
CFAMM00396462 CHEMBL2377337 Bioactive N,N-diethyl-2-fluoro-11-(2-fluoroethyl)-6H-thiochromeno[4,3-b]indole-6-carboxamide
CFAMM00396447 CHEMBL2377345 Bioactive N,N-diethyl-11-(2-fluoroethyl)-8-methyl-6H-thiochromeno[4,3-b]indole-6-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

39235 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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