CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM955
Family Name Melatonin receptor type 1A and Melatonin receptor type 1B ligand AGN-PC-07YQIF family
No. of Seeds 6 No. of Other Members 19
Family Centroid CFAMM00166434 Functional Category Bioactive with Natural Product
Superfamily Melatonin receptor type 1A and Melatonin receptor type 1B Binder Superfamily 2
Class Class 80

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Cholesteryl ester transfer protein Inhibitor Anacetrapib Family 3 63
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Integrin alpha-4 Inhibitor Firategrast Family 3 93
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Substance-P receptor Ligand DA-5018 Family 14 73
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Dapoxetine family 3 40
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Histamine H3 receptor Ligand A-349821 Family 49 228
Extracellular calcium-sensing receptor and Potassium voltage-g... 3 11
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Melatonin receptor type 1A and Melatonin receptor type 1B Liga... 33 98
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Renin Inhibitor Ro-65-7219 Family 10 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Caspase-1 inhibitor 5-(3-carbamoylnaphthalen-2-yl)oxy-3-[[(2S)... 1 11
Extracellular calcium-sensing receptor and Sodium-dependent no... 2 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Melatonin receptor type 1A ligand [7-methoxy-1-[2-(propanoylam... 3 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 4
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-7-[(4-ca... 3 14
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 12 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Prostaglandin E2 receptor EP4 subtype ligand 4-[(1S)-1-[[2-(tr... 2 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 1
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
Pol polyprotein inhibitor MDL 74538 family 11 1
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Free fatty acid receptor 1 ligand 3-[4-[[3-[2,6-dimethyl-4-[3-... 1 0
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Estrogen receptor ligand 2-(3-hydroxy-6-oxoxanthen-9-yl)-5-[[4... 1 2
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 13 0
Estrogen receptor and Estrogen receptor beta ligand SureCN1450... 1 1
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 15 13
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Androgen receptor and Estrogen receptor ligand estradiol benzo... 1 29
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 7
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-074LOQ... 3 0
Coagulation factor X and Trypsin-1 inhibitor methyl (E)-2-[(3-... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 4 3
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Cathepsin D inhibitor (E)-N-butyl-4-[1-(3,4,5-trimethoxybenzoy... 1 3
Bifunctional epoxide hydrolase 2 inhibitor SureCN4877195 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00317902 CHEMBL1095197 Bioactive AGN-PC-07ZF7H
CFAMM00317913 CHEMBL1095196 Bioactive AGN-PC-07ZF7G

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26231 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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