CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9582
Family Name Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[4-[(4-methylpiperazin-1-yl)methyl]anilino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00396630 Functional Category Bioactive
Superfamily Insulin receptor and ALK tyrosine kinase receptor Binder Superfamily
Class Class 1334

Cousin Family NamesSeedsMembers
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
JAK Inhibitor Momelotinib Family 33 83
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
ALK tyrosine kinase receptor and Insulin receptor ligand N-[(1... 3 6
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Vascular endothelial growth factor receptor 2 ligand urea deri... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 15 3
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-[3-(2-hydroxyeth... 2 1
Tyrosine-protein kinase ZAP-70 inhibitor AGN-PC-07CO7Z family 1 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00396622 CHEMBL1946801 Bioactive CHEMBL1946801
CFAMM00396621 CHEMBL1946800 Bioactive CHEMBL1946800
CFAMM00396630 CHEMBL2022968 Bioactive 2-[[5-chloro-2-[4-[(4-methylpiperazin-1-yl)methyl]anilino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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