CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9594
Family Name Vascular endothelial growth factor receptor 1 and Receptor-type tyrosine-protein kinase FLT3 ligand CHEMBL1983963 family
No. of Seeds 2 No. of Other Members 11
Family Centroid CFAMM00223854 Functional Category Bioactive
Superfamily Peptide deformylase, mitochondrial and Serine/threonine-protein kinase Chk1 Binder Superfamily
Class Class 1877

Cousin Family NamesSeedsMembers
MK-6096 family 3 69
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Peptide deformylase, mitochondrial Inhibitor Furo[2,3d]pyrimid... 2 10
Serine/threonine-protein kinase Chk1 Inhibitor N-(5,6-diphenyl... 9 100
5-hydroxytryptamine receptor 2C Ligand 6-methyl-4-(piperazin-1... 1 0
Sodium-dependent serotonin transporter Inhibitor 4-furan-2-yl-... 2 10
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Prelamin-A/C inhibitor CHEMBL1395532 family 1 10
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 6 1
Mu-type opioid receptor ligand AGN-PC-075GEP family 1 2
Histamine H4 receptor and Histamine H3 receptor ligand 7-(fura... 2 2
Vascular endothelial growth factor receptor 1 ligand CHEMBL197... 1 2
Glycogen synthase kinase-3 beta inhibitor 2-(furan-3-yl)-N-[2-... 3 3
Activated CDC42 kinase 1 inhibitor 6-(4-methylsulfonylphenyl)-... 2 0
Activated CDC42 kinase 1 inhibitor 6-[4-(2-morpholin-4-ylethox... 7 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Neuropeptide Y receptor type 5 ligand SureCN2658856 family 6 0
Dual specificity protein kinase CLK4 and Dual specificity tyro... 6 2
Tyrosine-protein kinase JAK3 and Activated CDC42 kinase 1 inhi... 4 1
Glycogen synthase kinase-3 beta inhibitor N-[4-(4-amino-6-pyri... 1 0


External ID

Functional Category

Molecule Name

CFAMM00396708 CHEMBL401860 Bioactive 1-[4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl]-3-[2-fluoro-6-(trifluoromethyl)phenyl]urea
CFAMM00396706 CHEMBL194911 Bioactive GW768505A

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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